Genome-wide association studies (GWAS) of Alzheimer's disease are predominantly carried
out in European ancestry individuals despite the known variation in genetic architecture and …

Cardiometabolic diseases contribute more to global morbidity and mortality than any other
group of disorders. Polygenic risk scores (PRSs), the weighted summation of individually …

CRISPR base editing screens enable analysis of disease-associated variants at scale;
however, variable efficiency and precision confounds the assessment of variant-induced …

African populations are vastly underrepresented in genetic studies but have the most
genetic variation and face wide-ranging environmental exposures globally. Because …

Common genetic variants explain less variation in complex phenotypes than inferred from
family-based studies, and there is a debate on the source of this 'missing heritability'. We …

Summary The Trøndelag Health Study (HUNT) is a population-based cohort of∼ 229,000
individuals recruited in four waves beginning in 1984 in Trøndelag County, Norway …

Background Polygenic risk score (PRS) analyses are now routinely applied across
biomedical research. However, as PRS studies grow in size, there is an increased risk of …

Background The gut microbiome was reported to be associated with dyslipidemia in
previous observational studies. However, whether the composition of the gut microbiome …

Background Dyslipidaemia is highly prevalent in individuals with type 2 diabetes mellitus
(T2DM). Numerous studies have sought to disentangle the causal relationship between …

Genome-wide association studies (GWAS) revolutionized our understanding of common
genetic variation and its impact on common human disease and traits. Developed and …