[HTML][HTML] Shared genetic architectures of educational attainment in East Asian and European populations
Educational attainment (EduYears), a heritable trait often used as a proxy for cognitive
ability, is associated with various health and social outcomes. Previous genome-wide …
ability, is associated with various health and social outcomes. Previous genome-wide …
Comparing the relationships of genetically proxied PCSK9 inhibition with mood disorders, cognition, and dementia between men and women: a drug‐target …
AS Bell, DB Rosoff, LA Mavromatis, J Jung… - Journal of the …, 2022 - Am Heart Assoc
Background PCSK9 (proprotein convertase subtilisin/kexin type 9) inhibitors are important
therapeutic options for reducing cardiovascular disease risk; however, questions remain …
therapeutic options for reducing cardiovascular disease risk; however, questions remain …
[HTML][HTML] A two-sample Mendelian randomization study explores metabolic profiling of different glycemic traits
We assessed the causal relation of four glycemic traits and type 2 diabetes liability with 167
metabolites using Mendelian randomization with various sensitivity analyses and a reverse …
metabolites using Mendelian randomization with various sensitivity analyses and a reverse …
[HTML][HTML] Understanding the relationship between circulating lipids and risk of chronic kidney disease: a prospective cohort study and large-scale genetic analyses
Y Wang, L Zhang, W Zhang, M Tang, H Cui… - Journal of Translational …, 2023 - Springer
Background This study aims to comprehensively investigate the phenotypic and genetic
relationships between four common lipids (high-density lipoprotein cholesterol, HDL-C; low …
relationships between four common lipids (high-density lipoprotein cholesterol, HDL-C; low …
[HTML][HTML] Multi-trait discovery and fine-mapping of lipid loci in 125,000 individuals of African ancestry
AB Kamiza, SM Touré, F Zhou, O Soremekun… - Nature …, 2023 - nature.com
Most genome-wide association studies (GWAS) for lipid traits focus on the separate analysis
of lipid traits. Moreover, there are limited GWASs evaluating the genetic variants associated …
of lipid traits. Moreover, there are limited GWASs evaluating the genetic variants associated …
Novel methods for multi-ancestry polygenic prediction and their evaluations in 5.1 million individuals of diverse ancestry
Polygenic risk scores are becoming increasingly predictive of complex traits, but their
suboptimal performance in non-European ancestry populations raises questions about their …
suboptimal performance in non-European ancestry populations raises questions about their …
[HTML][HTML] Evaluating significance of European-associated index SNPs in the East Asian population for 31 complex phenotypes
Background Genome-wide association studies (GWASs) have identified many single-
nucleotide polymorphisms (SNPs) associated with complex phenotypes in the European …
nucleotide polymorphisms (SNPs) associated with complex phenotypes in the European …
[HTML][HTML] A linear weighted combination of polygenic scores for a broad range of traits improves prediction of coronary heart disease
Polygenic scores (PGS) for coronary heart disease (CHD) are constructed using GWAS
summary statistics for CHD. However, pleiotropy is pervasive in biology and disease …
summary statistics for CHD. However, pleiotropy is pervasive in biology and disease …
Causal graph among serum lipids and glycemic traits: a Mendelian randomization study
We systematically investigated the bidirectional causality among HDL cholesterol (HDL-C),
LDL cholesterol (LDL-C), triglycerides (TGs), fasting insulin (FI), and glycated hemoglobin …
LDL cholesterol (LDL-C), triglycerides (TGs), fasting insulin (FI), and glycated hemoglobin …
The case for precision medicine in the prevention, diagnosis, and treatment of cardiometabolic diseases in low-income and middle-income countries
Cardiometabolic diseases are the leading preventable causes of death in most
geographies. The causes, clinical presentations, and pathogenesis of cardiometabolic …
geographies. The causes, clinical presentations, and pathogenesis of cardiometabolic …