Diabetic kidney disease (DKD) is a severe diabetic complication that affects up to half of the
individuals with diabetes. Elevated blood glucose levels are a key underlying cause of DKD …

Background Genetic variants within nearly 1000 loci are known to contribute to modulation
of blood lipid levels. However, the biological pathways underlying these associations are …

Aims Diet quality might influence cardiometabolic health through epigenetic changes, but
this has been little investigated in adults. Our aims were to identify cytosine–phosphate …

Dyslipidemias are known risk factors for chronic diseases. Precision nutrition interventions
are designed according to characteristics, such as diet, phenotype, and genotype. This …

Purpose of review A polygenic risk score (PRS) is a measure of genetic liability to a disease
and is typically normally distributed in a population. Individuals in the upper tail of this …

Context Thyroid function has been associated with metabolic syndrome (MetS) in a number
of observational studies but the direction of effects and the exact causal mechanism of this …

Does the SARS-CoV-2 virus cause patients' chest X-Rays ground-glass opacities? Does an
IDH-mutation cause differences in patients' MRI images? Conventional causal discovery …

There is a long-standing debate about the magnitude of the contribution of gene-
environment interactions to phenotypic variations of complex traits owing to the low …

Most genome-wide association studies (GWAS) of major depression (MD) have been
conducted in samples of European ancestry. Here we report a multi-ancestry GWAS of MD …

Background: Preeclampsia is a leading cause of maternal morbidity, and dyslipidemia has
been associated with preeclampsia in observational studies. We use Mendelian …