Cocaine self-administration alters transcriptome-wide responses in the brain's reward circuitry
Background Global changes in gene expression underlying circuit and behavioral
dysregulation associated with cocaine addiction remain incompletely understood. Here, we …
dysregulation associated with cocaine addiction remain incompletely understood. Here, we …
The role of CREB in depression and antidepressant treatment
JA Blendy - Biological psychiatry, 2006 - Elsevier
Major depressive disorder is a severe clinical problem across the globe, with a lifetime risk
of 10%–30% for women and 7%–15% for men. The World Health Organization ranks major …
of 10%–30% for women and 7%–15% for men. The World Health Organization ranks major …
Fast-acting antidepressants rapidly stimulate ERK signaling and BDNF release in primary neuronal cultures
Recent preclinical and clinical studies demonstrate that three functionally different
compounds, the NMDA receptor channel blocker ketamine, mGlu 2/3 receptor antagonist …
compounds, the NMDA receptor channel blocker ketamine, mGlu 2/3 receptor antagonist …
Estrogen signaling in metabolic inflammation
R Monteiro, D Teixeira, C Calhau - Mediators of inflammation, 2014 - Wiley Online Library
There is extensive evidence supporting the interference of inflammatory activation with
metabolism. Obesity, mainly visceral obesity, is associated with a low‐grade inflammatory …
metabolism. Obesity, mainly visceral obesity, is associated with a low‐grade inflammatory …
Genome-wide analysis of chromatin regulation by cocaine reveals a role for sirtuins
Changes in gene expression contribute to the long-lasting regulation of the brain's reward
circuitry seen in drug addiction; however, the specific genes regulated and the …
circuitry seen in drug addiction; however, the specific genes regulated and the …
Crocin: A fighter against inflammation and pain
Crocin, a water-soluble carotenoid, is known as a pharmacologically active compound,
particularly for its potent anti-oxidant activity. The present work provides a comprehensive …
particularly for its potent anti-oxidant activity. The present work provides a comprehensive …
The role of glucagon-like peptide-1 receptor agonists (GLP-1 RA) in diabetes-related neurodegenerative diseases
D Cheng, S Yang, X Zhao, G Wang - Drug design, development …, 2023 - Taylor & Francis
Recent clinical guidelines have emphasized the importance of screening for cognitive
impairment in older adults with diabetes, however, there is still a lack of understanding about …
impairment in older adults with diabetes, however, there is still a lack of understanding about …
A role for repressive histone methylation in cocaine-induced vulnerability to stress
Substance abuse increases an individual's vulnerability to stress-related illnesses, which is
presumably mediated by drug-induced neural adaptations that alter subsequent responses …
presumably mediated by drug-induced neural adaptations that alter subsequent responses …
Differentiation of mouse Neuro 2A cells into dopamine neurons
RG Tremblay, M Sikorska, JK Sandhu… - Journal of neuroscience …, 2010 - Elsevier
Neuro 2A (N2a) is a mouse neural crest-derived cell line that has been extensively used to
study neuronal differentiation, axonal growth and signaling pathways. A convenient …
study neuronal differentiation, axonal growth and signaling pathways. A convenient …
Is glycogen synthase kinase-3 a central modulator in mood regulation?
X Li, RS Jope - Neuropsychopharmacology, 2010 - nature.com
Little is known regarding the mechanisms underlying the complex etiology of mood
disorders, represented mainly by major depressive disorder and bipolar disorder. The 1996 …
disorders, represented mainly by major depressive disorder and bipolar disorder. The 1996 …