Genomic technologies inform the complex genetic basis of polygenic inflammatory bowel
disease (IBD) as well as Mendelian disease-associated IBD. Aiming to diagnose patients …

Over the course of the past decade, genome‐wide association studies (GWAS) have
revolutionised our understanding of complex disease genetics. One of the diseases that has …

Background & Aims Inflammatory bowel diseases (IBDs)(Crohn's disease [CD], ulcerative
colitis) are global diseases. Similarities and differences in disease presentation and …

There is a growing body of evidence reinforcing the unique connections between the host
microbiome, health, and diseases. Due to the extreme importance of the symbiotic …

Inflammatory bowel disease (IBD) is an immune-mediated chronic intestinal disorder with
major phenotypes: ulcerative colitis (UC) and Crohn's disease (CD). Multiple studies have …

Background & Aims Activating transcription factor 4 (ATF4) regulates genes involved in the
inflammatory response, amino acid metabolism, autophagy, and endoplasmic reticulum …

Over the past century, the incidence of inflammatory bowel disease (IBD) in high-income
countries has shown a sharp rise that then plateaued, and a similar trend has been …

The exact pathogenesis of inflammatory bowel disease (IBD), a chronic gastrointestinal
inflammatory disease comprising Crohn's disease and ulcerative colitis, remains unclear …

Highlights•Epigenetics is a therapeutically tractable mechanism linking genetics and
environmental cues in IBD.•Variants of human epigenetic regulators or regulatory regions …

Genotype imputation of the human leukocyte antigen (HLA) region is a cost-effective means
to infer classical HLA alleles from inexpensive and dense SNP array data. In the research …