Studies of Crohn's disease have consistently implicated NOD2 as the most important gene
in disease pathogenesis since first being identified in 2001. Thereafter, genome-wide …

Background Observational studies have described racial differences in inflammatory bowel
disease (IBD) genetics, clinical manifestations, and outcomes. Whether race impacts …

Very early onset inflammatory bowel disease (VEO-IBD) represents a unique and growing
subset of patients with inflammatory bowel disease (IBD). Some VEO-IBD patients present …

Inflammatory bowel disease (IBD), which include Crohn's disease (CD) and ulcerative colitis
(UC), exhibits a complex multifactorial pathogenesis involving genetic susceptibility …

Background The human leucocyte antigen (HLA) complex, located at chromosome 6p21. 3
is a highly polymorphic region containing the classical class I and II HLA genes. The region …

Background A non-synonymous single nucleotide polymorphism of the ATG16L1 gene,
T300A, is a major Crohn's disease (CD) susceptibility allele, and is known to be associated …

Background Genetic factors increase the risk of irritable bowel syndrome (IBS). Analysis of
single nucleotide polymorphisms (SNPs) has been used in IBS patients, but the findings are …

Introduction: Crohn's disease (CD) is a chronic, disabling disease of the gastrointestinal tract
that mostly affects young adults. Despite extensive research, the pathogenesis of CD is still …

Background Inflammatory bowel disease (IBD) is a chronic disease of unknown etiology in
which genetic factors contribute to development of disease. Single nucleotide …

F2 and recombinant inbred lines (RILs) populations are very commonly used in plant
genetic mapping studies. Although genome-wide genetic markers like single nucleotide …