The perineuronal 'safety'net? Perineuronal net abnormalities in neurological disorders
Perineuronal nets (PNN) are extracellular matrix (ECM) assemblies that preferentially
ensheath parvalbumin (PV) expressing interneurons. Converging evidence indicates that …
ensheath parvalbumin (PV) expressing interneurons. Converging evidence indicates that …
A framework for the investigation of rare genetic disorders in neuropsychiatry
De novo and inherited rare genetic disorders (RGDs) are a major cause of human morbidity,
frequently involving neuropsychiatric symptoms. Recent advances in genomic technologies …
frequently involving neuropsychiatric symptoms. Recent advances in genomic technologies …
Genetic reduction of matrix metalloproteinase-9 promotes formation of perineuronal nets around parvalbumin-expressing interneurons and normalizes auditory cortex …
TH Wen, S Afroz, SM Reinhard, AR Palacios… - Cerebral …, 2018 - academic.oup.com
Abnormal sensory responses associated with Fragile X Syndrome (FXS) and autism
spectrum disorders include hypersensitivity and impaired habituation to repeated stimuli …
spectrum disorders include hypersensitivity and impaired habituation to repeated stimuli …
Translation-relevant EEG phenotypes in a mouse model of Fragile X Syndrome
Identification of comparable biomarkers in humans and validated animal models will
facilitate pre-clinical to clinical therapeutic pipelines to treat neurodevelopmental disorders …
facilitate pre-clinical to clinical therapeutic pipelines to treat neurodevelopmental disorders …
Sensory processing phenotypes in fragile X syndrome
Fragile X syndrome (FXS) is a neurodevelopmental disorder that causes intellectual
disability. It is a leading known genetic cause of autism. In addition to cognitive, social, and …
disability. It is a leading known genetic cause of autism. In addition to cognitive, social, and …
Of men and mice: modeling the fragile X syndrome
R Dahlhaus - Frontiers in molecular neuroscience, 2018 - frontiersin.org
The Fragile X Syndrome (FXS) is one of the most common forms of inherited intellectual
disability in all human societies. Caused by the transcriptional silencing of a single gene, the …
disability in all human societies. Caused by the transcriptional silencing of a single gene, the …
Increased aperiodic gamma power in young boys with Fragile X Syndrome is associated with better language ability
CL Wilkinson, CA Nelson - Molecular autism, 2021 - Springer
Background The lack of robust and reliable clinical biomarkers in Fragile X Syndrome (FXS),
the most common inherited form of intellectual disability, has limited the successful …
the most common inherited form of intellectual disability, has limited the successful …
Auditory EEG biomarkers in fragile X syndrome: clinical relevance
LE Ethridge, LA De Stefano, LM Schmitt… - Frontiers in integrative …, 2019 - frontiersin.org
Sensory hypersensitivities are common and distressing features of Fragile X Syndrome
(FXS). While there are many drug interventions that reduce behavioral deficits in Fmr1 mice …
(FXS). While there are many drug interventions that reduce behavioral deficits in Fmr1 mice …
Clinical applications of EEG power spectra aperiodic component analysis: A mini-review
Objective The present mini-review summarizes recent clinical findings related to the analysis
of the aperiodic component of EEG (electroencephalographic) power spectra, making them …
of the aperiodic component of EEG (electroencephalographic) power spectra, making them …
[HTML][HTML] Human models are needed for studying human neurodevelopmental disorders
X Zhao, A Bhattacharyya - The American Journal of Human Genetics, 2018 - cell.com
The analysis of animal models of neurological disease has been instrumental in furthering
our understanding of neurodevelopment and brain diseases. However, animal models are …
our understanding of neurodevelopment and brain diseases. However, animal models are …