The tryptophan catabolite or kynurenine pathway in COVID-19 and critical COVID-19: a systematic review and meta-analysis

AF Almulla, T Supasitthumrong… - BMC Infectious …, 2022 - Springer
Abstract Background Coronavirus disease 2019 (COVID-19) is accompanied by activated
immune-inflammatory pathways and oxidative stress, which both induce indoleamine-2, 3 …

Peculiarities of the T cell immune response in COVID-19

D Kudlay, I Kofiadi, M Khaitov - Vaccines, 2022 - mdpi.com
Understanding the T cell response to SARS-CoV-2 is critical to vaccine development,
epidemiological surveillance, and control strategies for this disease. This review provides …

Tryptophan regulates Drosophila zinc stores

E Garay, N Schuth, A Barbanente… - Proceedings of the …, 2022 - National Acad Sciences
Zinc deficiency is commonly attributed to inadequate absorption of the metal. Instead, we
show that body zinc stores in Drosophila melanogaster depend on tryptophan consumption …

Psychological outcomes of COVID-19 survivors at sixth months after diagnose: the role of kynurenine pathway metabolites in depression, anxiety, and stress

M Kucukkarapinar, A Yay-Pence, Y Yildiz… - Journal of Neural …, 2022 - Springer
Abstract Coronavirus disease 2019 (COVID-19) has resulted in long-term psychiatric
symptoms because of the immunologic response to the virus itself as well as fundamental …

Cross-talk between red blood cells and plasma influences blood flow and omics phenotypes in severe COVID-19

SM Recktenwald, G Simionato, MGM Lopes… - Elife, 2022 - elifesciences.org
Abstract Coronavirus disease 2019 (COVID-19) is caused by the Severe Acute Respiratory
Syndrome Coronavirus 2 (SARS-CoV-2) and can affect multiple organs, among which is the …

Metabolic profiling at COVID-19 onset shows disease severity and sex-specific dysregulation

FC Ceballos, A Virseda-Berdices, S Resino… - Frontiers in …, 2022 - frontiersin.org
Background metabolic changes through SARS-CoV-2 infection has been reported but not
fully comprehended. This metabolic dysregulation affects multiple organs during COVID-19 …

Kynurenine pathway in Coronavirus disease (COVID‐19): potential role in prognosis

M Cihan, Ö Doğan, C Ceran Serdar… - Journal of clinical …, 2022 - Wiley Online Library
Background It is known that inflammatory responses play an important role in the
pathophysiology of COVID‐19. Aims In this study, we aimed to examine the role of …

Tryptophan: Its metabolism along the kynurenine, serotonin, and indole pathway in malignant melanoma

B Hubková, M Valko-Rokytovská, B Čižmárová… - International Journal of …, 2022 - mdpi.com
(1) Background: Tryptophan metabolism is known to be one of the important mechanisms
used by cancer to evade immune surveillance. Altered tryptophan metabolism was studied …

Unbalanced IDO1/IDO2 endothelial expression and skewed keynurenine pathway in the pathogenesis of COVID-19 and Post-COVID-19 pneumonia

M Chilosi, C Doglioni, C Ravaglia, G Martignoni… - Biomedicines, 2022 - mdpi.com
Despite intense investigation, the pathogenesis of COVID-19 and the newly defined long
COVID-19 syndrome are not fully understood. Increasing evidence has been provided of …

Dramatic decrease of vitamin K2 subtype menaquinone-7 in COVID-19 patients

H Mangge, F Prueller, C Dawczynski, P Curcic, Z Sloup… - Antioxidants, 2022 - mdpi.com
(1) Background: Vitamin K (VK) is a fat-soluble compound with a common chemical
structure, a 2-methyl-1, 4-naphthoquinone ring, and a variable aliphatic side-chain. VK is …