Exosomes as mediators of intercellular crosstalk in metabolism

R Isaac, FCG Reis, W Ying, JM Olefsky - Cell metabolism, 2021 - cell.com
Exosomes are nanoparticles secreted by all cell types and are a large component of the
broader class of nanoparticles termed extracellular vesicles (EVs). Once secreted …

A review of the biological role of miRNAs in prostate cancer suppression and progression

AS Doghish, A Ismail, HA El-Mahdy, MA Elkady… - International journal of …, 2022 - Elsevier
Prostate cancer (PC) is the third-leading cause of cancer-related deaths worldwide.
Although the current treatment strategies are progressing rapidly, PC is still representing a …

Predicting effective microRNA target sites in mammalian mRNAs

V Agarwal, GW Bell, JW Nam, DP Bartel - elife, 2015 - elifesciences.org
MicroRNA targets are often recognized through pairing between the miRNA seed region
and complementary sites within target mRNAs, but not all of these canonical sites are …

Interplay between miRNAs and human diseases

P Paul, A Chakraborty, D Sarkar… - Journal of cellular …, 2018 - Wiley Online Library
MicroRNAs (miRNAs) are endogenous, non‐coding RNAs, which have evoked a great deal
of interest due to their importance in many aspects of homeostasis and diseases …

Osteoclast-derived exosomal miR-214-3p inhibits osteoblastic bone formation

D Li, J Liu, B Guo, C Liang, L Dang, C Lu, X He… - Nature …, 2016 - nature.com
Emerging evidence indicates that osteoclasts direct osteoblastic bone formation. MicroRNAs
(miRNAs) have a crucial role in regulating osteoclast and osteoblast function. However …

Absolute quantification by droplet digital PCR versus analog real-time PCR

CM Hindson, JR Chevillet, HA Briggs, EN Gallichotte… - Nature …, 2013 - nature.com
Nanoliter-sized droplet technology paired with digital PCR (ddPCR) holds promise for highly
precise, absolute nucleic acid quantification. Our comparison of microRNA quantification by …

[HTML][HTML] miR-122–a key factor and therapeutic target in liver disease

S Bandiera, S Pfeffer, TF Baumert, MB Zeisel - Journal of hepatology, 2015 - Elsevier
Being the largest internal organ of the human body with the unique ability of self-
regeneration, the liver is involved in a wide variety of vital functions that require highly …

MicroRNAs: history, biogenesis, and their evolving role in animal development and disease

M Bhaskaran, M Mohan - Veterinary pathology, 2014 - journals.sagepub.com
The discovery of microRNAs (miRNAs) in 1993 followed by developments and discoveries
in small RNA biology have redefined the biological landscape by significantly altering the …

Long noncoding RNA MALAT1 controls cell cycle progression by regulating the expression of oncogenic transcription factor B-MYB

V Tripathi, Z Shen, A Chakraborty, S Giri… - PLoS …, 2013 - journals.plos.org
The long noncoding MALAT1 RNA is upregulated in cancer tissues and its elevated
expression is associated with hyper-proliferation, but the underlying mechanism is poorly …

Development of micro RNA therapeutics is coming of age

E Van Rooij, S Kauppinen - EMBO molecular medicine, 2014 - embopress.org
Micro RNA s (mi RNA s) play key regulatory roles in diverse biological processes and are
frequently dysregulated in human diseases. Thus, mi RNA s have emerged as a class of …