Neurological complications and infection mechanism of SARS-COV-2

D Wan, T Du, W Hong, L Chen, H Que, S Lu… - Signal Transduction and …, 2021 - nature.com
Abstract Currently, SARS-CoV-2 has caused a global pandemic and threatened many lives.
Although SARS-CoV-2 mainly causes respiratory diseases, growing data indicate that SARS …

Infection mechanism of SARS-COV-2 and its implication on the nervous system

EE Reza-Zaldívar, MA Hernández-Sapiéns… - Frontiers in …, 2021 - frontiersin.org
In late December 2019, multiple atypical pneumonia cases resulted in severe acute
respiratory syndrome caused by a pathogen identified as a novel coronavirus SARS-CoV-2 …

[HTML][HTML] Acute transverse myelitis (ATM): clinical review of 43 patients with COVID-19-associated ATM and 3 post-vaccination ATM serious adverse events with the …

GC Román, F Gracia, A Torres, A Palacios… - Frontiers in …, 2021 - frontiersin.org
Introduction Although acute transverse myelitis (ATM) is a rare neurological condition (1.34-
4.6 cases per million/year) COVID-19-associated ATM cases have occurred during the …

Elucidating the neuropathologic mechanisms of SARS-CoV-2 infection

M Pacheco-Herrero, LO Soto-Rojas… - Frontiers in …, 2021 - frontiersin.org
The current pandemic caused by the new severe acute respiratory syndrome coronavirus 2
(SARS-CoV-2) has become a public health emergency. To date, March 1, 2021, coronavirus …

[HTML][HTML] NLRP3 inflammasome activation and SARS-CoV-2-mediated hyperinflammation, cytokine storm and neurological syndromes

D Dutta, J Liu, H Xiong - International journal of physiology …, 2022 - ncbi.nlm.nih.gov
Despite the introduction of vaccines and drugs for SARS-CoV-2, the COVID-19 pandemic
continues to spread throughout the world. In severe COVID-19 patients, elevated levels of …

SARS-CoV-2 poorly replicates in cells of the human blood-brain barrier without associated deleterious effects

O Constant, J Barthelemy, K Bollore, E Tuaillon… - Frontiers in …, 2021 - frontiersin.org
Various neurological symptoms have been associated to severe acute respiratory syndrome
coronavirus 2 (SARS-CoV-2) infection including headache, fever, anosmia, ageusia, but …

Bioinformatics and system biology approaches to identify pathophysiological impact of COVID-19 to the progression and severity of neurological diseases

MH Rahman, HK Rana, S Peng, MG Kibria… - Computers in biology …, 2021 - Elsevier
Abstract The Coronavirus Disease 2019 (COVID-19) still tends to propagate and increase
the occurrence of COVID-19 across the globe. The clinical and epidemiological analyses …

The ferret as a model system for neocortex development and evolution

C Gilardi, N Kalebic - Frontiers in Cell and Developmental Biology, 2021 - frontiersin.org
The neocortex is the largest part of the cerebral cortex and a key structure involved in human
behavior and cognition. Comparison of neocortex development across mammals reveals …

The microglial NLRP3 inflammasome is involved in human SARS-CoV-2 cerebral pathogenicity: A report of three post-mortem cases

VF Cama, J Marín-Prida, N Acosta-Rivero… - Journal of …, 2021 - Elsevier
We herein report, by using confocal immunofluorescence, the colocalization of the SARS-
CoV-2 nucleocapsid within neurons, astrocytes, oligodendrocytes and microglia in three …

Human Brain Organoids as an In Vitro Model System of Viral Infectious Diseases

X Su, P Yue, J Kong, X Xu, Y Zhang, W Cao… - Frontiers in …, 2022 - frontiersin.org
Brain organoids, or brainoids, have shown great promise in the study of central nervous
system (CNS) infection. Modeling Zika virus (ZIKV) infection in brain organoids may help …