Towards interpretable imaging genomics analysis: Methodological developments and applications

X Cen, W Dong, W Lv, Y Zhao, F Dubee, AFA Mentis… - Information …, 2023 - Elsevier
Identifying the relationship between imaging features and genetic variation (a term coined
“imaging genomics”) offers valuable insight into the pathogenesis of cancer, as well as …

[HTML][HTML] The genetic relationships between brain structure and schizophrenia

EM Stauffer, RAI Bethlehem, L Dorfschmidt… - Nature …, 2023 - nature.com
Genetic risks for schizophrenia are theoretically mediated by genetic effects on brain
structure but it has been unclear which genes are associated with both schizophrenia and …

[HTML][HTML] Human cortex development is shaped by molecular and cellular brain systems

LD Lotter, A Saberi, JY Hansen, B Misic, C Paquola… - bioRxiv, 2023 - ncbi.nlm.nih.gov
Human brain morphology undergoes complex changes over the lifespan. Despite recent
progress in tracking brain development via normative models, current knowledge of …

[HTML][HTML] Genetic architecture of the structural connectome

M Wainberg, NJ Forde, S Mansour, I Kerrebijn… - Nature …, 2024 - nature.com
Myelinated axons form long-range connections that enable rapid communication between
distant brain regions, but how genetics governs the strength and organization of these …

[HTML][HTML] A Unifying Hypothesis for the Genome Dynamics Proposed to Underlie Neuropsychiatric Phenotypes

GS Gericke - Genes, 2024 - mdpi.com
The sheer number of gene variants and the extent of the observed clinical and molecular
heterogeneity recorded in neuropsychiatric disorders (NPDs) could be due to the magnified …

[HTML][HTML] Brain-charting autism and attention deficit hyperactivity disorder reveals distinct and overlapping neurobiology

SA Bedford, MC Lai, MV Lombardo, B Chakrabarti… - medRxiv, 2023 - ncbi.nlm.nih.gov
Background Autism and attention deficit hyperactivity disorder (ADHD) are heterogeneous
neurodevelopmental conditions with complex underlying neurobiology. Despite overlapping …

The causal relationship between gut microbiota, brain volume, and intelligence: a two-step Mendelian randomization analysis

S Yao, JZ Han, J Guo, X Wang, L Qian, H Wu, W Shi… - Biological …, 2024 - Elsevier
Background Growing evidence indicates that dynamic changes in gut microbiome can affect
intelligence; however, whether these relationships are causal remains elusive. We aimed to …

[HTML][HTML] Proteins in Scalp Hair of Preschool Children

CR Rovnaghi, K Singhal, RD Leib, M Xenochristou… - Psych, 2024 - mdpi.com
Background. Early childhood experiences have long-lasting effects on subsequent mental
and physical health, education, and employment. The measurement of these effects relies …

[HTML][HTML] The overlapping genetic architecture of psychiatric disorders and cortical brain structure

Z Sha, V Warrier, RAI Bethlehem, LM Schultz… - bioRxiv, 2023 - ncbi.nlm.nih.gov
Both psychiatric vulnerability and cortical structure are shaped by the cumulative effect of
common genetic variants across the genome. However, the shared genetic underpinnings …

[HTML][HTML] A bipolar taxonomy of adult human brain sulcal morphology related to timing of fetal sulcation and trans-sulcal gene expression gradients

WE Snyder, PE Vértes, V Kyriakopoulou, K Wagstyl… - bioRxiv, 2023 - ncbi.nlm.nih.gov
We developed a computational pipeline (now provided as a resource) for measuring
morphological similarity between cortical surface sulci to construct a sulcal phenotype …