Validation of biomarkers of aging

M Moqri, C Herzog, JR Poganik, K Ying, JN Justice… - Nature medicine, 2024 - nature.com
The search for biomarkers that quantify biological aging (particularly 'omic'-based
biomarkers) has intensified in recent years. Such biomarkers could predict aging-related …

[HTML][HTML] A systematic review of biological, social and environmental factors associated with epigenetic clock acceleration

L Oblak, J van der Zaag, AT Higgins-Chen… - Ageing research …, 2021 - Elsevier
Aging involves a diverse set of biological changes accumulating over time that leads to
increased risk of morbidity and mortality. Epigenetic clocks are now widely used to quantify …

Effect of long-term caloric restriction on DNA methylation measures of biological aging in healthy adults from the CALERIE trial

R Waziry, CP Ryan, DL Corcoran, KM Huffman… - Nature Aging, 2023 - nature.com
The geroscience hypothesis proposes that therapy to slow or reverse molecular changes
that occur with aging can delay or prevent multiple chronic diseases and extend healthy …

Genome-wide association studies identify 137 genetic loci for DNA methylation biomarkers of aging

DL McCartney, JL Min, RC Richmond, AT Lu… - Genome biology, 2021 - Springer
Background Biological aging estimators derived from DNA methylation data are heritable
and correlate with morbidity and mortality. Consequently, identification of genetic and …

Epigenetic age prediction

DJ Simpson, T Chandra - Aging cell, 2021 - Wiley Online Library
Advanced age is the main common risk factor for cancer, cardiovascular disease and
neurodegeneration. Yet, more is known about the molecular basis of any of these groups of …

Clinical biomarker-based biological aging and risk of cancer in the UK Biobank

JKL Mak, CE McMurran, R Kuja-Halkola, P Hall… - British journal of …, 2023 - nature.com
Background Despite a clear link between aging and cancer, there has been inconclusive
evidence on how biological age (BA) may be associated with cancer incidence. Methods We …

Human age reversal: Fact or fiction?

AA Johnson, BW English, MN Shokhirev… - Aging …, 2022 - Wiley Online Library
Although chronological age correlates with various age‐related diseases and conditions, it
does not adequately reflect an individual's functional capacity, well‐being, or mortality risk …

DNA methylation-based age clocks: From age prediction to age reversion

R Noroozi, S Ghafouri-Fard, A Pisarek… - Ageing Research …, 2021 - Elsevier
Aging as an irretrievable occurrence throughout the entire life is characterized by a
progressive decline in physiological functionality and enhanced disease vulnerability …

[HTML][HTML] Biomarkers of COVID-19 and technologies to combat SARS-CoV-2

L Zhang, H Guo - Advances in Biomarker Sciences and Technology, 2020 - Elsevier
Due to the unprecedented public health crisis caused by COVID-19, our first contribution to
the newly launching journal, Advances in Biomarker Sciences and Technology, has abruptly …

“GrimAge,” an epigenetic predictor of mortality, is accelerated in major depressive disorder

E Protsenko, R Yang, B Nier, V Reus… - Translational …, 2021 - nature.com
Major depressive disorder (MDD) is associated with premature mortality and is an
independent risk factor for a broad range of diseases, especially those associated with …