Altered motor learning and coordination in mouse models of autism spectrum disorder

KR Cording, HS Bateup - Frontiers in cellular neuroscience, 2023 - frontiersin.org
Autism spectrum disorder (ASD) is a complex neurodevelopmental disorder with increasing
prevalence. Over 1,000 risk genes have now been implicated in ASD, suggesting diverse …

How to Use the Cuprizone Model to Study De-and Remyelination

M Kipp - International Journal of Molecular Sciences, 2024 - mdpi.com
Multiple sclerosis (MS) is an autoimmune and inflammatory disorder affecting the central
nervous system whose cause is still largely unknown. Oligodendrocyte degeneration results …

[HTML][HTML] Key role of the gut–microbiota–brain axis via the subdiaphragmatic vagus nerve in demyelination of the cuprizone-treated mouse brain

X Wang, A Eguchi, Y Yang, L Chang, X Wan… - Neurobiology of …, 2023 - Elsevier
Multiple sclerosis (MS) is the most common demyelinating disease that attacks the central
nervous system. Dietary intake of cuprizone (CPZ) produces demyelination resembling that …

[HTML][HTML] Manganese overexposure induces Parkinson-like symptoms, altered lipid signature and oxidative stress in C57BL/6 J mouse

M Lu, P Deng, L Yang, X Wang, X Mei, C Zhou… - Ecotoxicology and …, 2023 - Elsevier
Although adequate intake of manganese (Mn) is essential to humans, Mn in excess is
neurotoxic. Exposure to extremely high doses of Mn results in “manganism”, a condition that …

Characterization of graded 6-Hydroxydopamine unilateral lesion in medial forebrain bundle of mice

J Cui, D Zhao, M Xu, Z Li, J Qian, N Song, J Wang… - Scientific reports, 2024 - nature.com
Parkinson's disease (PD) is the second most common age-related neurodegenerative
disease, with a progressive loss of dopaminergic cells and fibers. The purpose of this study …

Molecular and neuroimmune pharmacology of S1P receptor modulators and other disease-modifying therapies for multiple sclerosis

Y Kihara, J Chun - Pharmacology & therapeutics, 2023 - Elsevier
Multiple sclerosis (MS) is a neurological, immune-mediated demyelinating disease that
affects people in the prime of life. Environmental, infectious, and genetic factors have been …

Effect of 2-Week Naringin Supplementation on Neurogenesis and BDNF Levels in Ischemia–Reperfusion Model of Rats

E Yilmaz, G Acar, U Onal, E Erdogan, AK Baltaci… - NeuroMolecular …, 2024 - Springer
Background: Ischemic stroke is the leading cause of mortality and disability worldwide with
more than half of survivors living with serious neurological sequelae; thus, it has recently …

Endogenous Sox8 is a critical factor for timely remyelination and oligodendroglial cell repletion in the cuprizone model

D Freudenstein, M Lippert, JS Popp, J Aprato… - Scientific Reports, 2023 - nature.com
Genome-wide association studies identified a single nucleotide polymorphism (SNP)
downstream of the transcription factor Sox8, associated with an increased risk of multiple …

Customizable Open-Source Rotating Rod (Rotarod) Enables Robust Low-Cost Assessment of Motor Performance in Mice

JH Widjaja, DC Sloan, JA Hauger, BS Muntean - Eneuro, 2023 - eneuro.org
Reliable measurements of motor learning and coordination in mice are fundamental aspects
of neuroscience research. Despite the advent of deep-learning approaches for motor …

The Effect of Graphene Oxide Administration on the Brains of Male Mice: Behavioral Study and Assessment of Oxidative Stress

A Rhazouani, H Gamrani, L Gebrati, TA Kurniawan… - NeuroToxicology, 2024 - Elsevier
Graphene oxide (GO) nanoparticles are attracting growing interest in various fields, not least
because of their distinct characteristics and possible uses. However, concerns about their …