In vitro evaluation of nasal aerosol depositions: an insight for direct nose to brain drug delivery

A Maaz, IS Blagbrough, PA De Bank - Pharmaceutics, 2021 - mdpi.com
The nasal cavity is an attractive route for both local and systemic drug delivery and holds
great potential for access to the brain via the olfactory region, an area where the blood–brain …

From indoor exposure to inhaled particle deposition: A multiphase journey of inhaled particles

K Inthavong - Experimental and computational multiphase flow, 2020 - Springer
Indoor air quality and its effect on respiratory health are reliant on understanding the level of
inhalation exposure, particle inhalability, and particle deposition in the respiratory airway. In …

Numerical study of the effect of nasopharynx airway obstruction on the transport and deposition of nanoparticles in nasal airways

Q Sun, J Dong, Y Zhang, L Tian, J Tu - Experimental and Computational …, 2022 - Springer
Although there is abundant literature for both experimental and numerical studies of
respiratory aerosol exposure in nasal airways, research efforts concentrating on diseased …

Nasal airflow comparison in neonates, infant and adult nasal cavities using computational fluid dynamics

JV Corda, BS Shenoy, KA Ahmad, L Lewis… - Computer Methods and …, 2022 - Elsevier
Background and objective Neonates are preferential nasal breathers up to 3 months of age.
The nasal anatomy in neonates and infants is at developing stages whereas the adult nasal …

Spray characteristics from nasal spray atomization

J Van Strien, P Petersen, P Lappas, L Yeo… - Journal of Aerosol …, 2022 - Elsevier
In addition to topical delivery, nasal sprays offer an alternative drug administration route to
the systemic circulation, therefore avoiding the need for painful, invasive delivery …

Development of a computational fluid dynamics model for mucociliary clearance in the nasal cavity

Y Shang, K Inthavong, J Tu - Journal of biomechanics, 2019 - Elsevier
Intranasal drug delivery has attracted significant attention because of the opportunity to
deliver systemic drugs directly to the blood stream. However, the mucociliary clearance …

Primary break-up and atomization characteristics of a nasal spray

K Shrestha, J Van Strien, N Singh, K Inthavong - Plos one, 2020 - journals.plos.org
The primary objective of this research was to extract the essential information needed for
setting atomization break up models, specifically, the Linear Instability Sheet Atomization …

Computational optimization of delivery parameters to guide the development of targeted Nasal spray

J Du, X Shao, JMC Bouteiller, A Lu, I Asante, S Louie… - Scientific Reports, 2023 - nature.com
Airborne transmission by droplets and aerosols is known to play a critical role in the spread
of many viruses amongst which are the common flu and the more recent SARS-CoV-2 …

Effect of different degrees of adenoid hypertrophy on pediatric upper airway aerodynamics: a computational fluid dynamics study

Z Hu, J Dong, M Lou, J Zhang, R Ma, Y Wang… - … and Modeling in …, 2023 - Springer
To improve the diagnostic accuracy of adenoid hypertrophy (AH) in children and prevent
further complications in time, it is important to study and quantify the effects of different …

The impact of nasal adhesions on airflow and mucosal cooling–A computational fluid dynamics analysis

P Senanayake, H Salati, E Wong, K Bradshaw… - Respiratory Physiology …, 2021 - Elsevier
Nasal adhesions are a known postoperative complication following surgical procedures for
nasal airway obstruction (NAO); and are a common cause of surgical failure, with patients …