Over the past 2000 years, tuberculosis (TB) has claimed more lives than any other infectious
disease. In 2020 alone, TB was responsible for 1.5 million deaths worldwide, comparable to …

The ever-increasing incidence of drug-resistant Mycobacterium tuberculosis infections has
invigorated the focus on the discovery and development of novel treatment options. The …

Ribosome hibernation is a key survival strategy bacteria adopt under environmental stress,
where a protein, hibernation promotion factor (HPF), transitorily inactivates the ribosome …

Alternative ribosome subunit proteins are prevalent in the genomes of diverse bacterial
species, but their functional significance is controversial. Attempts to study microbial …

Mycobacterium tuberculosis (Mtb) causes one of humankind's deadliest diseases,
tuberculosis. Mtb protein synthesis machinery possesses several unique species-specific …

Mycobacterium tuberculosis, which causes tuberculosis, can undergo prolonged periods of
non-replicating persistence in the host. The mechanisms underlying this are not fully …

Ribosome profiling enables sequencing of ribosome-bound fragments of RNA, revealing
which transcripts are being translated as well as the position of ribosomes along mRNAs …

Abstract Transcription factors (TFs) of Mycobacterium tuberculosis (Mtb), an etiological agent
of tuberculosis, regulate a network of pathways that help prolong the survival of Mtb inside …

Message-specific translational regulation mechanisms shape the biogenesis of multimeric
oxidative phosphorylation (OXPHOS) enzyme in mitochondria from the yeast …

In the absence of a sensitive and specific diagnostic modality capable of detecting all forms
of tuberculosis (TB), proteomics may identify specific Mycobacterium tuberculosis (M. tb) …