Cardiogenesis is a complex developmental process involving multiple overlapping stages of
cell fate specification, proliferation, differentiation, and morphogenesis. Precise …

The past two decades of angiogenesis research have identified a wealth of pro-and
antiangiogenic signals originating from the tissue environment, which control blood vessel …

In mammals, enlargement of the heart during embryonic development is primarily
dependent on the increase in cardiomyocyte numbers. Shortly after birth, however …

In the past few years, a considerable amount of effort has been devoted toward the
development of biomimetic scaffolds for cardiac tissue engineering. However, most of the …

Cardiovascular disease is a leading cause of death worldwide, and thus there remains great
interest in regenerative approaches to treat heart failure. In the past 20 years, the field of …

Rationale: Recent evidence indicates that a few human microRNAs (miRNAs), in particular
hsa-miR-199a-3p and hsa-miR-590-3p, stimulate proliferation of cardiomyocytes and, once …

Recent findings employing the mdx mouse model for Duchenne muscular dystrophy (DMD)
have revealed that muscle satellite stem cells play a direct role in contributing to disease …

The human heart's failure to replace ischemia-damaged myocardium with regenerated
muscle contributes significantly to the worldwide morbidity and mortality associated with …

While clinical gene therapy celebrates its first successes, with several products already
approved for clinical use and several hundreds in the final stages of the clinical approval …

Cardiovascular diseases, the number 1 cause of death worldwide, are frequently associated
with apoptotic death of cardiac myocytes. Since cardiomyocyte apoptosis is a highly …