The neurovascular unit and systemic biology in stroke—implications for translation and treatment

S Tiedt, AM Buchan, M Dichgans, I Lizasoain… - Nature Reviews …, 2022 - nature.com
Ischaemic stroke is a leading cause of disability and death for which no acute treatments
exist beyond recanalization. The development of novel therapies has been repeatedly …

The gut-brain axis in multiple sclerosis. Is its dysfunction a pathological trigger or a consequence of the disease?

B Parodi, N Kerlero de Rosbo - Frontiers in immunology, 2021 - frontiersin.org
A large and expending body of evidence indicates that the gut-brain axis likely plays a
crucial role in neurological diseases, including multiple sclerosis (MS). As a whole, the gut …

PIEZO2 in somatosensory neurons controls gastrointestinal transit

MR Servin-Vences, RM Lam, A Koolen, Y Wang… - Cell, 2023 - cell.com
The gastrointestinal tract is in a state of constant motion. These movements are tightly
regulated by the presence of food and help digestion by mechanically breaking down and …

Genetics of irritable bowel syndrome: shifting gear via biobank-scale studies

M Camilleri, A Zhernakova, I Bozzarelli… - Nature Reviews …, 2022 - nature.com
The pathophysiology of irritable bowel syndrome (IBS) is multifactorial and probably
involves genetic predisposition and the effect of environmental factors. Unlike other …

[HTML][HTML] Gut microbiome plays a vital role in post-stroke injury repair by mediating neuroinflammation

A Huang, L Ji, Y Li, Y Li, Q Yu - International Immunopharmacology, 2023 - Elsevier
Cerebral stroke is a common neurological disease and often causes severe neurological
deficits. With high morbidity, mortality, and disability rates, stroke threatens patients' life …

Gastroparesis in Parkinson disease: pathophysiology, and clinical management

H Soliman, B Coffin, G Gourcerol - Brain Sciences, 2021 - mdpi.com
Patients with Parkinson disease (PD) experience a range of non-motor symptoms, including
gastrointestinal symptoms. These symptoms can be present in the prodromal phase of the …

Chronic intestinal pseudo‐obstruction in adults: a practical guide to identify patient subgroups that are suitable for more specific treatments

G Basilisco, M Marchi, M Coletta - Neurogastroenterology & …, 2024 - Wiley Online Library
Chronic intestinal pseudo‐obstruction is a rare and heterogeneous syndrome characterized
by recurrent symptoms of intestinal obstruction with radiological features of dilated small or …

Gastroparesis

M Camilleri, KM Sanders - Gastroenterology, 2022 - Elsevier
Gastroparesis is characterized by symptoms suggestive of, and objective evidence of,
delayed gastric emptying in the absence of mechanical obstruction. This review addresses …

Emerging insights between gut microbiome dysbiosis and Parkinson's disease: Pathogenic and clinical relevance

M Bi, L Feng, J He, C Liu, Y Wang, H Jiang… - Ageing Research …, 2022 - Elsevier
Parkinson's disease (PD) is a complicated neurodegenerative disease, of which
gastrointestinal disturbance appears prior to motor symptoms. Numerous studies have shed …

Neurogenic Bowel Dysfunction in Patients with Spinal Cord Injury and Multiple Sclerosis—An Updated and Simplified Treatment Algorithm

FS Magnuson, P Christensen, A Krassioukov… - Journal of Clinical …, 2023 - mdpi.com
Neurogenic bowel dysfunction (NBD) is a common condition in individuals with spinal cord
injury (SCI) or multiple sclerosis (MS). It usually entails constipation, difficult evacuation of …