While population-scale neuroimaging studies offer the promise of discovery and
characterisation of subtle risk factors, massive sample sizes increase the power for both …

Emerging research on neuroplasticity processes in psychosis spectrum illnesses—from the
synaptic to the macrocircuit levels—fill key gaps in our models of pathophysiology and open …

Our understanding of the genetics of the human cerebral cortex is limited both in terms of the
diversity and the anatomical granularity of brain structural phenotypes. Here we conducted a …

White matter tracts form the structural basis of large-scale brain networks. We applied brain-
wide tractography to diffusion images from 30,810 adults (UK Biobank) and found significant …

Schizophrenia is a highly heritable psychiatric disorder characterized by widespread
functional and structural brain abnormalities. However, previous association studies …

Background Major depressive disorder (MDD), bipolar disorder (BD) and schizophrenia
(SCZ) share clinical features and genetic bases. Magnetic Resonance Imaging (MRI) …

While major psychiatric disorders lack signature diagnostic neuropathologies akin to
dementias, classic postmortem studies have established microstructural involvement, ie …

Background Schizophrenia is characterized by complex psychiatric symptoms and unclear
pathological mechanisms. Most previous studies have focused on the morphological …

Childhood maltreatment (CM) leads to a lifelong susceptibility to mental ill-health which
might be reflected by its effects on adult brain structure, perhaps indirectly mediated by its …

Psychotic symptoms are a cross-sectional dimension affecting multiple diagnostic
categories, despite schizophrenia represents the prototype of psychoses. Initially, dopamine …