From NSAIDs to glucocorticoids and beyond

A Sinniah, S Yazid, RJ Flower - Cells, 2021 - mdpi.com
Our interest in inflammation and its treatment stems from ancient times. Hippocrates used
willow bark to treat inflammation, and many centuries later, salicylic acid and its derivative …

The immunology of SARS-CoV-2 infection and vaccines in solid organ transplant recipients

D Dęborska-Materkowska, D Kamińska - Viruses, 2021 - mdpi.com
Since its outbreak in December 2019, the coronavirus disease 2019 (COVID-19) pandemic,
caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), led to an …

Dexamethasone impairs the expression of antimicrobial mediators in lipopolysaccharide-activated primary macrophages by inhibiting both expression and function of …

JD O'Neil, OO Bolimowska, SA Clayton… - Frontiers in …, 2023 - frontiersin.org
Glucocorticoids potently inhibit expression of many inflammatory mediators, and have been
widely used to treat both acute and chronic inflammatory diseases for more than seventy …

[HTML][HTML] Immune and ionic mechanisms mediating the effect of dexamethasone in severe COVID-19

AA Chimote, AO Alshwimi, M Chirra… - Frontiers in …, 2023 - frontiersin.org
Introduction Severe COVID-19 is characterized by cytokine storm, an excessive production
of proinflammatory cytokines that contributes to acute lung damage and death …

Sex‐dependent improvement in traumatic brain injury outcomes after liposomal delivery of dexamethasone in mice

G Baudo, H Flinn, M Holcomb, A Tiwari… - Bioengineering & …, 2024 - Wiley Online Library
Traumatic brain injury (TBI) can have long‐lasting physical, emotional, and cognitive
consequences due to the neurodegeneration caused by its robust inflammatory response …

A clinical update on SARS-CoV-2: Pathology and development of potential inhibitors

DD Singh, I Han, EH Choi, DK Yadav - Current Issues in Molecular …, 2023 - mdpi.com
SARS-CoV-2 (severe acute respiratory syndrome) is highly infectious and causes severe
acute respiratory distress syndrome (SARD), immune suppression, and multi-organ failure …

Effect of dexamethasone dose on outcomes in acute COVID-19 disease: A systematic review and meta-analysis

TAC Snow, N Arulkumaran, M Singer, C Sang-Ho - Journal of Infection, 2023 - Elsevier
Introduction The impact of different doses of dexamethasone on outcomes from acute
COVID-19 pneumonia is unknown. Methods We performed a systematic review and meta …

Profound effects of dexamethasone on the immunological state, synthesis and secretion capacity of human testicular peritubular cells

YK Stepanov, JD Speidel, C Herrmann, N Schmid… - Cells, 2022 - mdpi.com
The functions of human testicular peritubular cells (HTPCs), forming a small compartment
located between the seminiferous epithelium and the interstitial areas of the testis, are not …

Glucocorticoid Signaling Pathway: From Bench to Bedside

NC Nicolaides, GP Chrousos - International Journal of Molecular …, 2023 - mdpi.com
Glucocorticoids were named by Hans Hugo Bruno Selye, the modern father of stress
concepts, for their important role in glucose metabolism [1]. These adrenal cortex-derived …

Determination of selected glucocorticoids in healthy foods by ultra-performance convergence chromatography–triple quadrupole mass spectrometry

G Yang, J Guo, H Yuan, L Sun, L Sha - Journal of Chromatography A, 2023 - Elsevier
The presence of glucocorticoids in healthy foods has recently become a topic of concern
because of their side effects. In this study, we developed a method based on ultra …