Chimeric antigen receptor T cell therapies: a review of cellular kinetic‐pharmacodynamic modeling approaches

A Chaudhury, X Zhu, L Chu, A Goliaei… - The Journal of …, 2020 - Wiley Online Library
Chimeric antigen receptor T cell (CAR‐T cell) therapies have shown significant efficacy in
CD19+ leukemias and lymphomas. There remain many challenges and questions for …

Mathematical deconvolution of CAR T-cell proliferation and exhaustion from real-time killing assay data

P Sahoo, X Yang, D Abler… - Journal of the …, 2020 - royalsocietypublishing.org
Chimeric antigen receptor (CAR) T-cell therapy has shown promise in the treatment of
haematological cancers and is currently being investigated for solid tumours, including high …

Quantitative systems pharmacology model of chimeric antigen receptor T‐cell therapy

D Hardiansyah, CM Ng - Clinical and translational science, 2019 - Wiley Online Library
Chimeric antigen receptor T‐cell (CART) therapy is a new and promising cancer therapy.
However, severe toxicity due to cytokine release syndrome (CRS) in CART‐treated patients …

Modeling CAR T-cell therapy with patient preconditioning

K Owens, I Bozic - Bulletin of Mathematical Biology, 2021 - Springer
Abstract The Federal Drug Administration approved the first Chimeric Antigen Receptor T-
cell (CAR T-cell) therapies for the treatment of several blood cancers in 2017, and efforts are …

[HTML][HTML] Computational analysis of cytokine release following bispecific T-cell engager therapy: applications of a logic-based model

G Selvaggio, S Parolo, P Bora, L Leonardelli… - Frontiers in …, 2022 - frontiersin.org
Bispecific T-cell engaging therapies harness the immune system to elicit an effective
anticancer response. Modulating the immune activation avoiding potential adverse effects …

[HTML][HTML] Mathematical model of a cytokine storm

I Kareva, F Berezovskaya, G Karev - bioRxiv, 2022 - ncbi.nlm.nih.gov
Cytokine storm is a life-threatening inflammatory response that is characterized by
hyperactivation of the immune system, and which can be caused by various therapies …

[HTML][HTML] Modeling interaction of Glioma cells and CAR T-cells considering multiple CAR T-cells bindings

R Li, P Sahoo, D Wang, Q Wang, CE Brown… - ImmunoInformatics, 2023 - Elsevier
Chimeric antigen receptor (CAR) T-cell based immunotherapy has shown its potential in
treating blood cancers, and its application to solid tumors is currently being extensively …

Study of dose-dependent combination immunotherapy using engineered T cells and IL-2 in cervical cancer

H Cho, Z Wang, D Levy - Journal of Theoretical Biology, 2020 - Elsevier
Adoptive T cell based immunotherapy is gaining significant traction in cancer treatment.
Despite its limited efficacy so far in treating solid tumors compared to hematologic cancers …

Cytokine storm mitigation for exogenous immune agonists

I Kareva, JL Gevertz - Mathematics of Control, Signals, and Systems, 2024 - Springer
Cytokine storm is a life-threatening inflammatory response characterized by hyperactivation
of the immune system. It can be caused by various therapies, auto-immune conditions, or …

Оптимальные стратегии CAR-T терапии лечения лейкемии в модели хищник-жертва Лотки-Вольтерры

НЛ Григоренко, ЕН Хайлов, ЭВ Григорьева… - … и механики УрО РАН, 2021 - mathnet.ru
Рассматривается управляемая математическая модель лечения лейкемии, в основе
которой лежит трехмерная модель хищник жертва Лотки Вольтерры. Эта модель …