The C-type lectins are a superfamily of proteins that recognize a broad repertoire of ligands
and that regulate a diverse range of physiological functions. Most research attention has …

Cells respond to diverse types of mechanical stimuli using a wide range of plasma
membrane-associated mechanosensitive receptors to convert extracellular mechanical cues …

Mutations in the polycystin proteins, PC-1 and PC-2, result in autosomal dominant polycystic
kidney disease (ADPKD) and ultimately renal failure. PC-1 and PC-2 enrich on primary cilia …

Autosomal dominant polycystic kidney disease (ADPKD) is caused by mutations in PKD 1 or
PKD 2 gene, encoding the polycystic kidney disease protein polycystin‐1 and the transient …

Abstract Autosomal Dominant Polycystic Kidney Disease (ADPKD) is a systemic disorder
associated with polycystic liver disease (PLD) and other extrarenal manifestations, the most …

Primary cilia play counterregulatory roles in cystogenesis—they inhibit cyst formation in the
normal renal tubule but promote cyst growth when the function of polycystins is impaired …

G protein‐coupled receptors (GPCRs) are the largest receptor superfamily. In this paper, we
try to employ physical‐chemical properties, which come from SVM‐Prot, to represent GPCR …

Abstract Polycystin-1 (PC-1) and PC-2 form a heteromeric ion channel complex that is
abundantly expressed in primary cilia of renal epithelial cells. This complex functions as a …

Mammalian cilia are ubiquitous appendages found on the apical surface of cells. Primary
and motile cilia are distinct in both morphology and function. Most cells have a solitary …

Naturally occurring mutations in two separate genes, PKD1 and PKD2, are responsible for
the vast majority of all cases of autosomal dominant polycystic kidney disease (ADPKD), one …