Mechanistic insights of chelator complexes with essential transition metals: antioxidant/pro-oxidant activity and applications in medicine

VA Timoshnikov, OY Selyutina, NE Polyakov… - International Journal of …, 2022 - mdpi.com
The antioxidant/pro-oxidant activity of drugs and dietary molecules and their role in the
maintenance of redox homeostasis, as well as the implications in health and different …

Recent developments on the potential biological applications of transition metal complexes of thiosemicarbazone derivatives

V Singh, VNV Palakkeezhillam, V Manakkadan… - Polyhedron, 2023 - Elsevier
This review talks about the synthesis, and coordination chemistry of thiosemicarbazone and
its bonding with transition metals like copper, nickel, zinc, palladium, and ruthenium and …

Nickel (II) complexes with polyhydroxybenzaldehyde and O, N, S tridentate thiosemicarbazone ligands: Synthesis, cytotoxicity, antimalarial activity, and molecular …

S Savir, JWK Liew, I Vythilingam, YAL Lim… - Journal of Molecular …, 2021 - Elsevier
A series of Schiff base metal complexes with the formulations [Ni (L1) PPh 3] Cl (1),[Ni (L2)
PPh 3] Cl (2),[Ni (L3) PPh 3](3), and [Ni (L4) PPh 3](4)(where L1= 2, 3, 4 …

Synthesis, Characterization, Antibacterial and Antifungal Activities Evaluation of Metal Complexes With Benzaldehyde‐4‐methylthiosemicarbazone Derivatives

A Jaafar, N Mansour, A Fix‐Tailler, M Allain… - …, 2022 - Wiley Online Library
Herein, to develop the comprehension of the microbiological activity of metal complexes
based on benzaldehyde‐N4‐thiosemicarbazone derivatives, we described the synthesis …

Dual active 1, 4-dihydropyridine derivatives: Design, green synthesis and in vitro anti-cancer and anti-oxidant studies

P Anaikutti, P Makam - Bioorganic Chemistry, 2020 - Elsevier
The present work describes the design of 1, 4-dihydropyridines (1, 4-DHPs) with diverse
variations in structural and functional groups. The physico-chemical properties and drug-like …

Indolyl-4H-chromenes: Multicomponent one-pot green synthesis, in vitro and in silico, anticancer and antioxidant studies

P Anaikutti, M Selvaraj, J Prabhakaran… - Journal of Molecular …, 2022 - Elsevier
The present work describes the simple, economical and eco-friendly multicomponent one-
pot synthesis of indolyl-4H-chromene derivatives. It is being achieved by reacting …

Synthesis and Evaluation of Antiproliferative Activity, Topoisomerase IIα Inhibition, DNA Binding and Non-Clinical Toxicity of New Acridine–Thiosemicarbazone …

G Sousa, MCF de Almeida, LL Lócio, VL Dos Santos… - Pharmaceuticals, 2022 - mdpi.com
In this study, we report the synthesis of twenty new acridine–thiosemicarbazone derivatives
and their antiproliferative activities. Mechanisms of action such as the inhibition of …

Synthesis, single-crystal exploration, hirshfeld surface analysis, and DFT investigation of the thiosemicarbazones

M Ashfaq, A Ali, MN Tahir, A Kuznetsov… - Journal of Molecular …, 2022 - Elsevier
Thiosemicarbazones (TSCs) are considered as one of the most significant classes of
organic compounds in recent time due to their applications in pharmaceutical chemistry …

Synthesis, characterization, antioxidant and antiparasitic activities new naphthyl-thiazole derivatives

NFN Santos, NSB Junior, JF de Oliveira… - Experimental …, 2023 - Elsevier
Abstract In this work, 13 thiosemicarbazones (1a–m) and 16 thiazoles (2a–p) were obtained,
which were properly characterized by spectroscopic and spectrometric techniques. The …

Synthesis, in-silico, in vitro and DFT assessments of substituted imidazopyridine derivatives as potential antimalarials targeting hemoglobin degradation pathway

OO Ferreira, SN Mali, B Jadhav… - Journal of …, 2023 - nchr.elsevierpure.com
Malaria is a serious illness transmitted through the bite of an infected mosquito, which is
caused by a type of parasite called plasmodium and can be fatal if left untreated. Thus …