A large body of preclinical and clinical data shows that the central melanocortin system is a
promising therapeutic target for treating various metabolic disorders such as obesity and …

The hypothalamic melanocortin system is critically involved in sensing stored energy and
communicating this information throughout the brain, including to brain regions controlling …

Members of the melanocortin receptor (MCR) family that recognize different melanocortin
peptides mediate a broad spectrum of cellular processes including energy homeostasis …

Summary The melanocortin-3 receptor (MC3R) is a negative regulator of the central
melanocortin circuitry via presynaptic expression on agouti-related protein (AgRP) nerve …

Social deficits are debilitating features of many psychiatric disorders, including autism. While
time-intensive behavioral therapy is moderately effective, there are no pharmacological …

The melanocortin-3 receptor (MC3R) regulates GABA release from agouti-related protein
(AgRP) nerve terminals and thus tonically suppresses multiple circuits involved in feeding …

Abstract The melanocortin-3 receptor (MC3R) acts presynaptically to regulate GABA release
from agouti-related protein (AgRP) nerve terminals and thus may be a negative regulator of …

Melanocortin 3 receptors (MC3R) and melanocortin 4 receptors (MC4R) are vital in
regulating a variety of functions across many species. For example, the dysregulation of …

The brain controls energy homeostasis by regulating food intake through signaling within
the melanocortin system. Whilst we understand the role of the hypothalamus within this …

Although mammals resist both acute weight loss and weight gain, the neural circuitry
mediating bi-directional defense against weight change is incompletely understood. Global …