Abstract In the Tohoku Medical Megabank project, genome and omics analyses of
participants in two cohort studies were performed. A part of the data is available at the …

Monocytes contribute to immune responses as a source for subsets of dendritic cells and
macrophages. Human blood monocytes are classified as classical, non-classical and …

Background: We established a community-based cohort study to assess the long-term
impact of the Great East Japan Earthquake on disaster victims and gene-environment …

Epigenetic reprogramming underlies specification of immune cell lineages, but patterns that
uniquely define immune cell types and the mechanisms by which they are established …

Population‐based prospective cohort studies are indispensable for modern medical
research as they provide important knowledge on the influences of many kinds of genetic …

Epigenetic differences may help to distinguish between PTSD cases and trauma-exposed
controls. Here, we describe the results of the largest DNA methylation meta-analysis of …

Background Previous studies using candidate gene and genome-wide approaches have
identified epigenetic changes in DNA methylation (DNAm) associated with posttraumatic …

Aims/hypothesis IRS2 is an important molecular switch that mediates insulin signalling in the
liver. IRS2 dysregulation is responsible for the phenomenon of selective insulin resistance …

We launched an integrative multi-omics database, iMETHYL (http://imethyl. iwate-
megabank. org). iMETHYL provides whole-DNA methylation (~ 24 million autosomal CpG …

Attention-deficit/hyperactivity disorder (ADHD) is a neurodevelopmental disorder that often
persists into adulthood. ADHD and related personality traits, such as impulsivity and …