Long non-coding RNAs: definitions, functions, challenges and recommendations
Genes specifying long non-coding RNAs (lncRNAs) occupy a large fraction of the genomes
of complex organisms. The term 'lncRNAs' encompasses RNA polymerase I (Pol I), Pol II …
of complex organisms. The term 'lncRNAs' encompasses RNA polymerase I (Pol I), Pol II …
Genome-wide analysis of human long noncoding RNAs: a provocative review
CP Ponting, W Haerty - Annual review of genomics and human …, 2022 - annualreviews.org
Do long noncoding RNAs (lncRNAs) contribute little or substantively to human biology? To
address how lncRNA loci and their transcripts, structures, interactions, and functions …
address how lncRNA loci and their transcripts, structures, interactions, and functions …
Transcription regulation by long non-coding RNAs: mechanisms and disease relevance
J Ferrer, N Dimitrova - Nature Reviews Molecular Cell Biology, 2024 - nature.com
Long non-coding RNAs (lncRNAs) outnumber protein-coding transcripts, but their functions
remain largely unknown. In this Review, we discuss the emerging roles of lncRNAs in the …
remain largely unknown. In this Review, we discuss the emerging roles of lncRNAs in the …
A model for organization and regulation of nuclear condensates by gene activity
HH Schede, P Natarajan, AK Chakraborty… - Nature …, 2023 - nature.com
Condensation by phase separation has recently emerged as a mechanism underlying many
nuclear compartments essential for cellular functions. Nuclear condensates enrich nucleic …
nuclear compartments essential for cellular functions. Nuclear condensates enrich nucleic …
Systematic mapping of nuclear domain-associated transcripts reveals speckles and lamina as hubs of functionally distinct retained introns
The nucleus is highly compartmentalized through the formation of distinct classes of
membraneless domains. However, the composition and function of many of these structures …
membraneless domains. However, the composition and function of many of these structures …
[HTML][HTML] Merging established mechanisms with new insights: condensates, hubs, and the regulation of RNA polymerase II transcription
M Palacio, DJ Taatjes - Journal of Molecular Biology, 2022 - Elsevier
The regulation of RNA polymerase II (pol II) transcription requires a complex and context-
specific array of proteins and protein complexes, as well as nucleic acids and metabolites …
specific array of proteins and protein complexes, as well as nucleic acids and metabolites …
The chromatin-associated RNAs in gene regulation and cancer
J Tang, X Wang, D Xiao, S Liu, Y Tao - Molecular Cancer, 2023 - Springer
Eukaryotic genomes are prevalently transcribed into many types of RNAs that translate into
proteins or execute gene regulatory functions. Many RNAs associate with chromatin directly …
proteins or execute gene regulatory functions. Many RNAs associate with chromatin directly …
[HTML][HTML] The apparent loss of PRC2 chromatin occupancy as an artifact of RNA depletion
RNA has been implicated in the recruitment of chromatin modifiers, and previous studies
have provided evidence in favor and against this idea. RNase treatment of chromatin is …
have provided evidence in favor and against this idea. RNase treatment of chromatin is …
HNRNPU facilitates antibody class-switch recombination through C-NHEJ promotion and R-loop suppression
B cells generate functionally different classes of antibodies through class-switch
recombination (CSR), which requires classical non-homologous end joining (C-NHEJ) to …
recombination (CSR), which requires classical non-homologous end joining (C-NHEJ) to …