The human organic anion and cation transporters are classified within two SLC
superfamilies. Superfamily SLCO (formerly SLC21A) consists of organic anion transporting …

1. The organic anion transporting polypeptides (humans OATP; other species Oatp) belong
to the SLCO gene superfamily of transporters and are twelve transmembrane domain …

The hepatic organic anion transporting polypeptides (OATPs) influence the
pharmacokinetics of several drug classes and are involved in many clinical drug–drug …

The inhibition of hepatic uptake transporters, such as OATP1B1, on the pharmacokinetics of
atorvastatin is unknown. Here, we investigate the effect of a model hepatic transporter …

Fluorescent tracer dyes represent an important class of sub-cellular probes and allow the
examination of cellular processes in real-time with minimal impact upon these processes …

The pregnane X receptor is a ligand-activated transcription factor that is abundantly
expressed in hepatocytes. Numerous drugs are pregnane X receptor ligands. To bind to …

Several recent studies show that inhibition of the hepatic transport proteins organic anion-
transporting polypeptide 1B1 (OATP1B1) and 1B3 (OATP1B3) can result in clinically …

The effects of single doses of intravenous (IV) ciprofloxacin and rifampin and of multiple
doses of rifampin on glyburide exposure and blood glucose levels were investigated in nine …

The two organic anion transporting polypeptides (OATPs) 1B1 and 1B3 are expressed at the
sinusoidal membrane of hepatocytes. They have a broad and overlapping substrate …

Probe drug cocktails are used clinically to assess the potential for drug–drug interactions
(DDIs), and in particular, DDIs resulting from coadministration of substrates and inhibitors of …