The therapeutic potential of natural dietary flavonoids against SARS-CoV-2 infection

Z Wang, L Yang - Nutrients, 2023 - mdpi.com
The exploration of non-toxic and cost-effective dietary components, such as epigallocatechin
3-gallate and myricetin, for health improvement and disease treatment has recently attracted …

Feasibility Study of Developing a Saline-Based Antiviral Nanoformulation Containing Lipid-Soluble EGCG: A Potential Nasal Drug to Treat Long COVID

N Frank, D Dickinson, W Garcia, Y Liu, H Yu, J Cai… - Viruses, 2024 - mdpi.com
A recent estimate indicates that up to 23.7 million Americans suffer from long COVID, and
approximately one million workers may be out of the workforce each day due to associated …

Epigallocatechin gallate regulates the myeloid-specific transcription factor PU. 1 in macrophages

M Karpurapu, KK Kakarala, S Chung, Y Nie, A Koley… - Plos one, 2024 - journals.plos.org
Our previous research demonstrated that PU. 1 regulates expression of the genes involved
in inflammation in macrophages. Selective knockdown of PU. 1 in macrophages ameliorated …

Concentrating all helper protein functions on a single entity allows rescue of recombinant Measles virus by transfection of just two plasmids

A Auste, MD Mühlebach - Journal of General Virology, 2022 - microbiologyresearch.org
The generation of recombinant measles virus (MeV) from manipulated genomes on plasmid
DNA is quite a complex and inefficient process. As a member of the order Mononegavirales …

Immunomodulation effects of isochlorogenic acid a from apple on RAW264. 7 cells via modulation of TLR2 and TLR4 target proteins

G Xu, Z Yu, W Zhao - Food Bioscience, 2024 - Elsevier
The incorporation of nutrients with immunomodulatory properties into the daily diet has
emerged as a pressing health requirement. The aim of this study was to screen apple …

[PDF][PDF] Evaluation of Aqueous Nanoformulations of Epigallocatechin-3-Gallate-Palmitate (EC16) against Human Coronavirus as a Potential Intervention Drug

N Frank, D Dickinson, W Garcia, L Xiao… - Biomed. J. Sci. Tech …, 2023 - camellix.com
Background: Chronic neurologic diseases are common sequelae of COVID. They severely
impact the quality of life and increase the burden on healthcare systems. The long COVID …

The Role of Green Tea Catechin Epigallocatechin Gallate (EGCG) and Mammalian Target of Rapamycin (mTOR) Inhibitor PP242 (Torkinib) in the Treatment of Spinal …

L Machova Urdzikova, V Cimermanova, K Karova… - Antioxidants, 2023 - mdpi.com
Spinal cord injury (SCI) is a devastating condition that has physical and psychological
consequences for patients. SCI is accompanied by scar formation and systemic …

Evaluation of Novel Nasal Mucoadhesive Nanoformulations Containing Lipid-Soluble EGCG for Long COVID Treatment

N Frank, D Dickinson, G Lovett, Y Liu, H Yu, J Cai… - Pharmaceutics, 2024 - mdpi.com
Following recovery from the acute infection stage of the SARS-CoV-2 virus (COVID-19),
survivors can experience a wide range of persistent Post-Acute Sequelae of COVID-19 …

In vivo evaluation of the antiretroviral activity of Melia azedarach against small ruminant lentiviruses in goat colostrum and milk

SCR Souza, RR Pinheiro, RM Peixoto… - Brazilian Journal of …, 2024 - Springer
This study aimed to evaluate in vivo the use of the extract from the leaves of Melia
azedarach in the ethyl acetate fraction at a concentration of 150 µg/mL as an antiretroviral …

Protease Inhibitors for Treating or Preventing Coronavirus Infection

RW Sabnis - ACS Medicinal Chemistry Letters, 2023 - ACS Publications
Protease Inhibitors for Treating or Preventing Coronavirus Infection Page 1 Protease
Inhibitors for Treating or Preventing Coronavirus Infection Ram W. Sabnis* Cite This: https://doi.org/10.1021/acsmedchemlett.3c00417 …