Polycystic ovary syndrome

AE Joham, RJ Norman, E Stener-Victorin… - The lancet Diabetes & …, 2022 - thelancet.com
Polycystic ovary syndrome (PCOS) affects 5–18% of women, and is a reproductive,
metabolic, and psychological condition with impacts across the lifespan. The cause is …

Deconstructing a syndrome: genomic insights into PCOS causal mechanisms and classification

M Dapas, A Dunaif - Endocrine reviews, 2022 - academic.oup.com
Polycystic ovary syndrome (PCOS) is among the most common disorders in women of
reproductive age, affecting up to 15% worldwide, depending on the diagnostic criteria …

The genetic basis of endometriosis and comorbidity with other pain and inflammatory conditions

N Rahmioglu, S Mortlock, M Ghiasi, PL Møller… - Nature …, 2023 - nature.com
Endometriosis is a common condition associated with debilitating pelvic pain and infertility.
A genome-wide association study meta-analysis, including 60,674 cases and 701,926 …

[HTML][HTML] Rare and common genetic determinants of metabolic individuality and their effects on human health

P Surendran, ID Stewart, VPW Au Yeung, M Pietzner… - Nature Medicine, 2022 - nature.com
Garrod's concept of 'chemical individuality'has contributed to comprehension of the
molecular origins of human diseases. Untargeted high-throughput metabolomic …

Genetic insights into biological mechanisms governing human ovarian ageing

KS Ruth, FR Day, J Hussain, A Martínez-Marchal… - Nature, 2021 - nature.com
Reproductive longevity is essential for fertility and influences healthy ageing in women,, but
insights into its underlying biological mechanisms and treatments to preserve it are limited …

Genetics of 35 blood and urine biomarkers in the UK Biobank

N Sinnott-Armstrong, Y Tanigawa, D Amar, N Mars… - Nature …, 2021 - nature.com
Clinical laboratory tests are a critical component of the continuum of care. We evaluate the
genetic basis of 35 blood and urine laboratory measurements in the UK Biobank (n …

[PDF][PDF] Androgen signaling regulates SARS-CoV-2 receptor levels and is associated with severe COVID-19 symptoms in men

RM Samuel, H Majd, MN Richter, Z Ghazizadeh… - Cell Stem Cell, 2020 - cell.com
SARS-CoV-2 infection has led to a global health crisis, and yet our understanding of the
disease and potential treatment options remains limited. The infection occurs through …

Epigenetic inheritance of polycystic ovary syndrome—challenges and opportunities for treatment

E Stener-Victorin, Q Deng - Nature Reviews Endocrinology, 2021 - nature.com
Polycystic ovary syndrome (PCOS) is the main cause of female infertility worldwide and is
associated with a substantially increased lifetime risk of comorbidities, including type 2 …

Androgen sensitivity gateway to COVID‐19 disease severity

CG Wambier, A Goren, S Vaño‐Galván… - Drug development …, 2020 - Wiley Online Library
In this communication, we present arguments for androgen sensitivity as a likely determinant
of COVID‐19 disease severity. The androgen sensitivity model explains why males are more …

Insulin resistance and PCOS: chicken or egg?

P Moghetti, F Tosi - Journal of endocrinological investigation, 2021 - Springer
PCOS is a common and heterogeneous endocrine disorder in women of reproductive age,
frequently associated with metabolic abnormalities. It was estimated that about 75% of these …