Abstract SARS-CoV-2, which causes COVID-19, was first identified in humans in late 2019
and is a coronavirus which is zoonotic in origin. As it spread around the world there has …

Single-cell 'omics methodology has yielded unprecedented insights based largely on data-
centric informatics for reducing, and thus interpreting, massive datasets. In parallel …

Substantial progress in molecular immunology, coupled with an increasing focus on
translational research and an enthusiasm for personalized medicine, has resulted in a rapid …

The role of the host immune response in determining the severity and duration of an
influenza infection is still unclear. In order to identify severity factors and more accurately …

The immune system is inordinately complex with many interacting components determining
overall outcomes. Mathematical and computational modelling provides a useful way in …

Chimeric antigen receptor (CAR) T-cell therapy shows promise for treating liquid cancers
and increasingly for solid tumors as well. While potential design strategies exist to address …

Emergent responses of the immune system result from the integration of molecular and
cellular networks over time and across multiple organs. High-content and high-throughput …

Asthma is a common condition caused by immune and respiratory dysfunction, and it is often
linked to allergy. A systems perspective may prove helpful in unravelling the complexity of …

One of the greatest challenges in biomedicine is to get a unified view of observations made
from the molecular up to the organism scale. Towards this goal, multiscale models have …

Recent mechanistic insights obtained from preclinical studies and the approval of the first
immunotherapies has motivated increasing number of academic investigators and …