[HTML][HTML] Long non-coding RNAs: definitions, functions, challenges and recommendations
Genes specifying long non-coding RNAs (lncRNAs) occupy a large fraction of the genomes
of complex organisms. The term 'lncRNAs' encompasses RNA polymerase I (Pol I), Pol II …
of complex organisms. The term 'lncRNAs' encompasses RNA polymerase I (Pol I), Pol II …
Developmental mechanisms underlying the evolution of human cortical circuits
P Vanderhaeghen, F Polleux - Nature Reviews Neuroscience, 2023 - nature.com
The brain of modern humans has evolved remarkable computational abilities that enable
higher cognitive functions. These capacities are tightly linked to an increase in the size and …
higher cognitive functions. These capacities are tightly linked to an increase in the size and …
A single-cell transcriptome atlas profiles early organogenesis in human embryos
The early window of human embryogenesis is largely a black box for developmental
biologists. Here we probed the cellular diversity of 4–6 week human embryos when …
biologists. Here we probed the cellular diversity of 4–6 week human embryos when …
[HTML][HTML] Cancer-associated fibroblast-specific lncRNA LINC01614 enhances glutamine uptake in lung adenocarcinoma
T Liu, C Han, P Fang, Z Ma, X Wang, H Chen… - Journal of Hematology & …, 2022 - Springer
Background Besides featured glucose consumption, recent studies reveal that cancer cells
might prefer “addicting” specific energy substrates from the tumor microenvironment (TME); …
might prefer “addicting” specific energy substrates from the tumor microenvironment (TME); …
[HTML][HTML] De novo birth of functional microproteins in the human lineage
Small open reading frames (sORFs) can encode functional" microproteins" that perform
crucial biological tasks. However, their size makes them less amenable to genomic analysis …
crucial biological tasks. However, their size makes them less amenable to genomic analysis …
Long noncoding RNAs: molecular modalities to organismal functions
We have known for decades that long noncoding RNAs (lncRNAs) can play essential
functions across most forms of life. The maintenance of chromosome length requires an …
functions across most forms of life. The maintenance of chromosome length requires an …
[HTML][HTML] Alternative splicing during mammalian organ development
Alternative splicing (AS) is pervasive in mammalian genomes, yet cross-species
comparisons have been largely restricted to adult tissues and the functionality of most AS …
comparisons have been largely restricted to adult tissues and the functionality of most AS …
[HTML][HTML] The molecular evolution of spermatogenesis across mammals
The testis produces gametes through spermatogenesis and evolves rapidly at both the
morphological and molecular level in mammals,,,,–, probably owing to the evolutionary …
morphological and molecular level in mammals,,,,–, probably owing to the evolutionary …
[HTML][HTML] Landscape and regulation of m6A and m6Am methylome across human and mouse tissues
Summary N 6-methyladenosine (m 6 A), the most abundant internal mRNA modification, and
N 6, 2′-O-dimethyladenosine (m 6 Am), found at the first-transcribed nucleotide, are two …
N 6, 2′-O-dimethyladenosine (m 6 Am), found at the first-transcribed nucleotide, are two …
Preclinical and clinical development of noncoding RNA therapeutics for cardiovascular disease
RNA modulation has become a promising therapeutic approach for the treatment of several
types of disease. The emerging field of noncoding RNA-based therapies has now come to …
types of disease. The emerging field of noncoding RNA-based therapies has now come to …