Cancer immunotherapies that engage immune cells to fight against tumors are proving to be
powerful weapons in combating cancer and are becoming increasingly utilized in the clinics …

Natural killer (NK) cells are lymphocytes with important roles in innate and adaptive immune
responses to tumours and viral infection. However, in certain chronic diseases, including …

Alteration in the expression of cell-surface proteins is a common consequence of malignant
transformation. Natural killer (NK) cells use an array of germline-encoded activating and …

Avoiding destruction by immune cells is a hallmark of cancer, yet how tumors ultimately
evade control by natural killer (NK) cells remains incompletely defined. Using global …

Antibodies targeting immune checkpoints are emerging as potent and viable cancer
therapies, but not all patients respond to these as single agents. Concurrently targeting …

Aging is the greatest risk factor for nearly all major chronic diseases, including
cardiovascular diseases, cancer, Alzheimer's and other neurodegenerative diseases of …

Natural killer (NK) cells are innate immune cells that are critical to the body's antitumor and
antimetastatic defense. As such, novel therapies are being developed to utilize NK cells as …

Transcriptomic signatures designed to predict melanoma patient responses to PD-1
blockade have been reported but rarely validated. We now show that intra-patient …

Antigen-specific CD8+ T cells in chronic viral infections and tumors functionally deteriorate,
a process known as exhaustion. Exhausted T cells are sustained by precursors of exhausted …

Immune 'checkpoint'inhibitors can increase the activity of tumor-resident cytotoxic
lymphocytes and have revolutionized cancer treatment. Current therapies block inhibitory …