Status epilepticus is a life-threatening neurological emergency that affects both adults and
children. Approximately 36% of episodes of status epilepticus do not respond to the current …

Fundamental work on the mechanisms leading to focal epileptic discharges in mesial
temporal lobe epilepsy (MTLE) often rests on the use of rodent models in which an initial …

Several neurodevelopmental and neuropsychiatric disorders are characterized by
intermittent episodes of pathological activity. Although genetic therapies offer the ability to …

KCC2, best known as the neuron-specific chloride-extruder that sets the strength and
polarity of GABAergic currents during neuronal maturation, is a multifunctional molecule that …

With the rapid increase in the use of optogenetics to investigate the nervous system, there is
a high demand for a neural interface that enables 2D mapping of electrophysiological neural …

Drug-resistant epilepsy remains a significant health-care burden. The most effective
treatment is surgery, but this is suitable for very few patients because of the unacceptable …

Seizures are complex pathological network events characterized by excessive and
hypersynchronized activity of neurons, including a highly diverse population of GABAergic …

Inhibitory synaptic mechanisms oppose epileptic network activity in the brain. The
breakdown in this inhibitory restraint and propagation of seizure activity has been linked to …

Epilepsy is a major health burden, calling for new mechanistic insights and therapies.
CRISPR-mediated gene editing shows promise to cure genetic pathologies, although …

Seizures can emerge from multiple or large foci in temporal lobe epilepsy, complicating
focally targeted strategies such as surgical resection or the modulation of the activity of …