Although the assumption of the neutral theory of molecular evolution—that some classes of
mutation have too small an effect on fitness to be affected by natural selection—seems …

Alcohol abuse causes widespread changes in gene expression in human brain, some of
which contribute to alcohol dependence. Previous microarray studies identified individual …

Long non-coding RNAs (lncRNAs) represent crucial transcriptional and post-transcriptional
gene regulators during antimicrobial responses in the host innate immune system. Studies …

Human promoters divide into 2 classes, the low CpG (LCG) and the high CpG (HCG), based
on their CpG dinucleotide content. The LCG class of promoters is hypermethylated and is …

Background Understanding the constraints that operate in mammalian gene promoter
sequences is of key importance to understand the evolution of gene regulatory networks …

Background Mammalian genomes consist of regions differing in GC content, referred to as
isochores or GC-content domains. The scientific debate is still open as to whether such …

We have applied a comparative phylogenomic analysis to study the evolutionary
relationships between GC content, CpG-dinucleotide content (CpGs), potential nuclear …

Background GC content varies greatly between different genomic regions in many
eukaryotes. In order to determine whether this organization named isochore organization …

Although gene duplication plays a major role in organismal evolution, it may also lead to
gene dosage imbalance, thereby having an immediate adverse effect on an organism's …

Chromosome-scale genome assemblies based on ultralong-read sequencing technologies
are able to illuminate previously intractable aspects of genome biology such as fine-scale …