Leukocyte integrins and their ligand interactions
Although critical for cell adhesion and migration during normal immune-mediated reactions,
leukocyte integrins are also involved in the pathogenesis of diverse clinical conditions …
leukocyte integrins are also involved in the pathogenesis of diverse clinical conditions …
Therapeutic anti‐integrin (α4 and αL) monoclonal antibodies: two‐edged swords?
R González‐Amaro, M Mittelbrunn… - …, 2005 - Wiley Online Library
Anti‐α4 and anti‐αL integrin chain monoclonal antibodies have shown a clear‐cut beneficial
effect in different animal models of autoimmune and inflammatory disorders as well as in …
effect in different animal models of autoimmune and inflammatory disorders as well as in …
RNA interference-mediated knockdown of CD49e (α5 integrin chain) in human thymic epithelial cells modulates the expression of multiple genes and decreases …
L Linhares-Lacerda, M Ribeiro-Alves, ACMA Nogueira… - BMC genomics, 2010 - Springer
Background The thymus is a central lymphoid organ, in which bone marrow-derived T cell
precursors undergo a complex process of maturation. Developing thymocytes interact with …
precursors undergo a complex process of maturation. Developing thymocytes interact with …
Paxillin selectively associates with constitutive and chemoattractant-induced high-affinity α4β1 integrins: implications for integrin signaling
SJ Hyduk, J Oh, H Xiao, M Chen, MI Cybulsky - Blood, 2004 - ashpublications.org
Leukocyte α4β1 integrins regulate hematopoietic and lymphoid development, as well as the
emigration of circulating cells to sites of inflammation. Because vascular cell adhesion …
emigration of circulating cells to sites of inflammation. Because vascular cell adhesion …
Eriodictyol decreases very late antigen-4 (VLA-4) expression, cellular adhesion, and migration through an NFκB-dependent pathway in monocytes
TC Huang, KY Tseng, SS Tsai, HJ Liu, CT Ho… - Journal of Functional …, 2010 - Elsevier
Very late antigen-4 (VLA-4)-mediated monocyte adhesion and transendothelial migration
are important events during immune surveillance and in the pathogenesis of inflammatory …
are important events during immune surveillance and in the pathogenesis of inflammatory …
Humanized immunoglobulin reactive with α4β7 integrin
PD Ponath, DJ Ringler, ST Jones, W Newman… - US Patent …, 2008 - Google Patents
The present invention relates to isolated nucleic acids encoding humanized
immunoglobulins having binding specificity for α4β7 integrin, isolated nucleic acids …
immunoglobulins having binding specificity for α4β7 integrin, isolated nucleic acids …
Homing of hemopoietic precursor cells to the fetal rat thymus: intercellular contact-controlled cell migration and development of the thymic microenvironment
R Brelinska, A Malinska - Cell and tissue research, 2005 - Springer
Colonization of rat thymic anlage by the first wave of hemopoietic precursor cells (HPc) was
investigated by means of transmission electron microscopy and immunocytochemistry. HPc …
investigated by means of transmission electron microscopy and immunocytochemistry. HPc …
β1 integrin cytoplasmic domain regulates the constitutive conformation detected by MAb 15/7, but not the ligand‐induced conformation
D Crommie, ME Hemler - Journal of cellular biochemistry, 1998 - Wiley Online Library
The anti-integrin ß1 MAb 15/7 sometimes may be a reporter of integrin activation or ligand
occupancy. However, certain ß1 tail deletions eliminate ligand binding despite inducing …
occupancy. However, certain ß1 tail deletions eliminate ligand binding despite inducing …
The adhesion of anti-CD3-activated mouse T cells to syngeneic colon adenocarcinoma cells is differentially regulated by protein tyrosine kinase-, protein kinase C …
WM MacKenzie, DW Hoskin, J Blay - Biochemical and biophysical research …, 1999 - Elsevier
The adhesion of anti-CD3-activated mouse T cells (AK-T cells) to syngeneic colon
adenocarcinoma (MCA-38) cells is mediated principally through the integrin VLA-4 (α4β1) …
adenocarcinoma (MCA-38) cells is mediated principally through the integrin VLA-4 (α4β1) …
Protein, polynucleotide, vector, host cell, composition, method for treating an illness, in-vitro method for predicting multiple sclerosis, and use of a protein or …
VC de ALMEIDA, B Chaves, CL Aquino… - US Patent App. 18 …, 2024 - Google Patents
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