Spatially resolved mass spectrometry at the single cell: recent innovations in proteomics and metabolomics

MJ Taylor, JK Lukowski… - Journal of the American …, 2021 - ACS Publications
Biological systems are composed of heterogeneous populations of cells that
intercommunicate to form a functional living tissue. Biological function varies greatly across …

Nucleic acid tests for clinical translation

M Li, F Yin, L Song, X Mao, F Li, C Fan, X Zuo… - Chemical …, 2021 - ACS Publications
Nucleic acids, including deoxyribonucleic acid (DNA) and ribonucleic acid (RNA), are
natural biopolymers composed of nucleotides that store, transmit, and express genetic …

Long non-coding RNAs: the regulatory mechanisms, research strategies, and future directions in cancers

N Gao, Y Li, J Li, Z Gao, Z Yang, Y Li, H Liu… - Frontiers in …, 2020 - frontiersin.org
The development and application of whole genome sequencing technology has greatly
broadened our horizons on the capabilities of long non-coding RNAs (lncRNAs). LncRNAs …

Integration of microfluidic channel on electrochemical-based nanobiosensors for monoplex and multiplex analyses: an overview

H Adam, SCB Gopinath, MKM Arshad, T Adam… - Journal of the Taiwan …, 2023 - Elsevier
Background Microfluidic devices have evolved into low-cost, simple, and powerful analytical
tool platforms. Herein, an electrochemically-based microfluidic nanobiosensor array for …

Towards small scale: Overview and applications of microfluidics in biotechnology

A Enders, A Grünberger, J Bahnemann - Molecular biotechnology, 2024 - Springer
Thanks to recent and continuing technological innovations, modern microfluidic systems are
increasingly offering researchers working across all fields of biotechnology exciting new …

[HTML][HTML] The role of Nucleic Acid Mimics (NAMs) on FISH-based techniques and applications for microbial detection

M Nácher-Vázquez, B Santos, NF Azevedo… - Microbiological …, 2022 - Elsevier
Fluorescent in situ hybridization (FISH) is a powerful tool that for more than 30 years has
allowed to detect and quantify microorganisms as well as to study their spatial distribution in …

Development of fluorescence in situ hybridization as a rapid, accurate method for detecting coliforms in water samples

JT Kuo, LL Chang, CY Yen, TH Tsai, YC Chang… - Biosensors, 2020 - mdpi.com
Coliform bacteria are indicators of water quality; however, most detection methods for
coliform bacteria are time-consuming and nonspecific. Here, we developed a fluorescence …

Inter and intra-tumoral heterogeneity as a platform for personalized therapies in medulloblastoma

M Danilenko, SC Clifford, EC Schwalbe - Pharmacology & Therapeutics, 2021 - Elsevier
Medulloblastoma is the most common malignant CNS tumor of childhood, affecting~ 350
patients/year in the USA. In 2020, most children are cured of their disease, however …

μDamID: A microfluidic approach for joint imaging and sequencing of protein-DNA interactions in single cells

N Altemose, A Maslan, C Rios-Martinez, A Lai… - Cell systems, 2020 - cell.com
DNA adenine methyltransferase identification (DamID) measures a protein's DNA-binding
history by methylating adenine bases near each protein-DNA interaction site and then …

Microfluidic Platform with Precisely Controlled Hydrodynamic Parameters and Integrated Features for Generation of Microvortices to Accurately Form and Monitor …

K Wen, AA Gorbushina, K Schwibbert… - … Biomaterials Science & …, 2024 - ACS Publications
Microorganisms often live in habitats characterized by fluid flow, and their adhesion to
surfaces in industrial systems or clinical settings may lead to pipe clogging, microbially …