The complex aetiology of type 2 diabetes makes effective screening, diagnosis and
prognosis a substantial challenge for the physician. The rapidly developing area of …

The mechanisms that predispose to hypertension, coronary artery disease (CAD), and type
2 diabetes (T2D) in individuals of normal weight are poorly understood. In contrast, in …

General cognitive function is substantially heritable across the human life course from
adolescence to old age. We investigated the genetic contribution to variation in this …

During the past 7 years, genome-wide association studies have shed light on the
contribution of common genomic variants to the genetic architecture of type 2 diabetes …

Lean body mass, consisting mostly of skeletal muscle, is important for healthy aging. We
performed a genome-wide association study for whole body (20 cohorts of European …

CME Harvard Review of Psychiatry offers CME for readers who complete questions about
featured articles. Questions can be accessed from the Harvard Review of Psychiatry website …

Insulin secretion has a crucial role in glucose homeostasis, and failure to secrete sufficient
insulin is a hallmark of type 2 diabetes. Genome-wide association studies (GWAS) have …

Primary open-angle glaucoma (POAG), the most common optic neuropathy, is a heritable
disease. Siblings of POAG cases have a ten-fold increased risk of developing the disease …

The concentrations of high-and low-density-lipoprotein cholesterol and triglycerides are
influenced by smoking, but it is unknown whether genetic associations with lipids may be …

The prevalence and incidence of type 2 diabetes, representing. 90% of all cases of diabetes,
are increasing rapidly throughout the world. The International Diabetes Federation has …