Mesenchymal stem/stromal cell therapy for COVID-19 pneumonia: potential mechanisms, current clinical evidence, and future perspectives

W Yao, L Shi, Y Zhang, H Dong, Y Zhang - Stem Cell Research & Therapy, 2022 - Springer
Abstract The coronavirus disease 2019 (COVID-19) pandemic, caused by severe acute
respiratory syndrome coronavirus 2 (SARS-CoV-2), has spread into more than 200 countries …

Mesenchymal stem cells: Biological characteristics and application in disease therapy

S Lou, Y Duan, H Nie, X Cui, J Du, Y Yao - Biochimie, 2021 - Elsevier
Mesenchymal stem cells (MSCs) are multipotent stem cells. In addition to the capacity for
self-renewal and multipotential differentiation, MSCs also have the following characteristics …

Efficacy of MSC in patients with severe COVID-19: analysis of the literature and a case study

M Grumet, J Sherman, BS Dorf - Stem cells translational …, 2022 - academic.oup.com
Patients with severe COVID-19 experience cytokine storm, an uncontrolled upregulation of
pro-inflammatory cytokines, which if unresolved leads to acute respiratory distress syndrome …

Mesenchymal stem cells and MSCs-derived extracellular vesicles in infectious diseases: From basic research to clinical practice

N Yudintceva, N Mikhailova, V Fedorov… - Bioengineering, 2022 - mdpi.com
Mesenchymal stem cells (MSCs) are attractive in various fields of regenerative medicine due
to their therapeutic potential and complex unique properties. Basic stem cell research and …

Stem cell therapy potency in personalizing severe COVID-19 treatment

A Basiri, F Mansouri, A Azari, P Ranjbarvan… - Stem Cell Reviews and …, 2021 - Springer
Currently, there are no specific and efficient vaccines or drugs for COVID-19, particularly in
severe cases. A wide range of variations in the clinical symptoms of different patients …

Effectivity of mesenchymal stem cells for bleomycin-induced pulmonary fibrosis: a systematic review and implication for clinical application

Y Zhao, Z Yan, Y Liu, Y Zhang, J Shi, J Li… - Stem cell research & …, 2021 - Springer
Pulmonary fibrosis (PF) is a chronic, progressive, fibrotic interstitial disease of the lung with
poor prognosis and without effective treatment currently. Data from previous coronavirus …

Umbilical cord blood transplantation: connecting its origin to its future

G Sanchez-Petitto, K Rezvani, M Daher… - Stem cells …, 2023 - academic.oup.com
Transplantation of umbilical cord blood (UCB) is an attractive alternative source of
hematopoietic stem cells (HSCs). The unique properties of cord blood and its distinct …

Knockdown of long noncoding RNA SAN rejuvenates aged adipose-derived stem cells via miR-143-3p/ADD3 axis

H Xiong, S Ren, J Chen, X Yang, Y Liu, Z Xu… - Stem Cell Research & …, 2023 - Springer
Background Senescent adipose-derived stem cells (ASCs) exhibit reduced therapeutic
efficacy during wound healing. Transcriptional regulation factors including long noncoding …

Regenerative medicine applications: An overview of clinical trials

A Petrosyan, PN Martins, K Solez, BE Uygun… - … in Bioengineering and …, 2022 - frontiersin.org
Insights into the use of cellular therapeutics, extracellular vesicles (EVs), and tissue
engineering strategies for regenerative medicine applications are continually emerging with …

Rescuing emergency cases of COVID-19 patients: an intelligent real-time MSC transfusion framework based on multicriteria decision-making methods

MA Alsalem, OS Albahri, AA Zaidan, JR Al-Obaidi… - Applied …, 2022 - Springer
Mesenchymal stem cells (MSCs) have shown promising ability to treat critical cases of
coronavirus disease 2019 (COVID-19) by regenerating lung cells and reducing immune …