Anti-SARS-CoV-2 Viral Activity of Sweet Potato Trypsin Inhibitor via Downregulation of TMPRSS2 Activity and ACE2 Expression In Vitro and In Vivo

WP Jiang, JS Deng, CC Yu, JG Lin… - International Journal of …, 2024 - mdpi.com
Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) has caused a global
pandemic. Known as COVID-19, it has affected billions of people worldwide, claiming …

The roles of the kynurenine pathway in COVID-19 neuropathogenesis

M Dehhaghi, M Heydari, HKS Panahi, SR Lewin… - Infection, 2024 - Springer
The severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is the causative agent
of the highly contagious respiratory disease Corona Virus Disease 2019 (COVID-19) that …

[HTML][HTML] Genetic and immunological insights into COVID-19 with acute myocardial infarction: integrated analysis of mendelian randomization, transcriptomics, and …

Z Zheng, Y Zhou, Y Song, P Ying, X Tan - Frontiers in Immunology, 2023 - frontiersin.org
Background Globally, most deaths result from cardiovascular diseases, particularly ischemic
heart disease. COVID-19 affects the heart, worsening existing heart conditions and causing …

Treponema pallidum recombinant protein Tp47 enhanced interleukin-6 secretion in human dermal fibroblasts through the toll-like receptor 2 via the p38, PI3K/Akt, and …

XQ Zheng, XQ Kong, Y He, YJ Wang, L Xie… - … et Biophysica Acta (BBA …, 2023 - Elsevier
Abstract Interleukin-6 (IL-6) is a multi-effective cytokine involved in multiple immune
responses. Whether fibroblasts also turn out to be a cytokine IL-6 factory during interaction …

Virus-Induced Acute Respiratory Distress Syndrome Causes Cardiomyopathy Through Eliciting Inflammatory Responses in the Heart

J Grune, G Bajpai, PT Ocak, E Kaufmann… - Circulation, 2024 - Am Heart Assoc
BACKGROUND: Viral infections can cause acute respiratory distress syndrome (ARDS),
systemic inflammation, and secondary cardiovascular complications. Lung macrophage …

The “Invisible Enemy” SARS-CoV-2: viral spread and drug treatment

A Tanase, A Manea, AD Scurtu, LM Bratu, D Chioran… - Medicina, 2022 - mdpi.com
Nowadays, severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection has
become the main subject of the scientific medical world and all World Organizations …

The critical impacts of cytokine storms in respiratory disorders

SR Tramboo, AME Elkhalifa, S Quibtiya, SI Ali… - Heliyon, 2024 - cell.com
Cytokine storm (CS) refers to the spontaneous dysregulated and hyper-activated
inflammatory reaction occurring in various clinical conditions, ranging from microbial …

[HTML][HTML] Hemophagocytic syndrome and COVID-19: A comprehensive review

MM Fadlallah, SM Salman, MM Fadlallah, H Rahal - Cureus, 2023 - ncbi.nlm.nih.gov
Hemophagocytic lymphohistiocytosis (HLH), a hyperinflammatory hyperferritinemic
syndrome, is triggered by various etiologies and diseases and can lead to multiorgan …

Regulation of immune responses to infection through interaction between stem cell-derived exosomes and toll-like receptors mediated by microRNA cargoes

MM Moghaddam, E Behzadi, H Sedighian… - Frontiers in Cellular …, 2024 - frontiersin.org
Infectious diseases are among the factors that account for a significant proportion of disease-
related deaths worldwide. The primary treatment approach to combat microbial infections is …

[HTML][HTML] IL1A regulates the inflammation in gout through the Toll-like receptors pathway

M Ling, J Gan, M Hu, F Pan, M Liu - International Journal of …, 2024 - ncbi.nlm.nih.gov
Objective: Gout is a dangerous metabolic condition related to monosodium urate (MSU). Our
aim is to study the molecular mechanisms underlying gout and to identify potential clinical …