The β-lactams retain a central place in the antibacterial armamentarium. In Gram-negative
bacteria, β-lactamase enzymes that hydrolyze the amide bond of the four-membered β …

This chapter analyzes the epidemiology of Carbapenem-Resistant Enterobacteriaceae
(CRE) as well as current and future treatment options against the increasingly resistant …

Modern medicine is threatened by the rising tide of antimicrobial resistance, especially
among Gram-negative bacteria, where resistance to β-lactams is most often mediated by β …

High-resistance rates in carbapenem-resistant GNB in many countries will inevitably
complicate treatment of serious infections in vulnerable patient groups and should …

Multidrug-resistant bacteria have on overwhelming impact on human health, as they cause
over 670,000 infections and 33,000 deaths annually in the European Union alone. Of these …

Carbapenem-resistant Enterobacteriaceae (CRE) have spread rapidly around the world in
the past few years, posing great challenges to human health. The plasmid-mediated …

Objectives To investigate the increase in the rates of OXA-48-like-producing isolates during
3 years of global surveillance. Methods Among 55?> 162 Enterobacterales isolates, 354 …

The rising incidence of bloodstream infections (BSI) due to Gram-negative bacteria (GNB)
with difficult-to-treat resistance (DTR) has been recognized as a global emergency. The aim …

Abstract Purpose of Review Gram-negative resistance is a growing concern globally.
Enterobacterales, formerly Enterobacteriaceae, have developed resistance mechanisms to …

Armamentarium against MDR Gram-negatives has expanded with the dominance of agents
active against ESBL and KPC producers. There is a need to prioritize MBL producers and …