Epilepsy and bipolar disorder
It is well recognized that mood disorders and epilepsy commonly co-occur. Despite this, our
knowledge regarding the relationship between epilepsy and bipolar disorder is limited …
knowledge regarding the relationship between epilepsy and bipolar disorder is limited …
Convergent lines of evidence support CAMKK2 as a schizophrenia susceptibility gene
Genes that are differentially expressed between schizophrenia patients and healthy controls
may have key roles in the pathogenesis of schizophrenia. We analyzed two large-scale …
may have key roles in the pathogenesis of schizophrenia. We analyzed two large-scale …
[HTML][HTML] High-quality exome sequencing of whole-genome amplified neonatal dried blood spot DNA
Stored neonatal dried blood spot (DBS) samples from neonatal screening programmes are
a valuable diagnostic and research resource. Combined with information from national …
a valuable diagnostic and research resource. Combined with information from national …
Recent challenges to the psychiatric diagnostic nosology: a focus on the genetics and genomics of neurodevelopmental disorders
YS Kim, MW State - International journal of epidemiology, 2014 - academic.oup.com
Recent advances in the genetics of neurodevelopmental disorder (NDD) have demonstrated
that rare mutations play a role not only in Mendelian syndromes, but in complex, common …
that rare mutations play a role not only in Mendelian syndromes, but in complex, common …
[HTML][HTML] JNK signalling mediates aspects of maternal immune activation: importance of maternal genotype in relation to schizophrenia risk
RL Openshaw, J Kwon, A McColl, JM Penninger… - Journal of …, 2019 - Springer
Background Important insight into the mechanisms through which gene-environmental
interactions cause schizophrenia can be achieved through preclinical studies combining …
interactions cause schizophrenia can be achieved through preclinical studies combining …
[HTML][HTML] GWAS meta analysis identifies TSNARE1 as a novel Schizophrenia/Bipolar susceptibility locus
We carried out a GWAS meta-analysis of combined mixed-ancestry schizophrenia,
schizoaffective, and bipolar cohorts that resulted in the identification of six genome-wide …
schizoaffective, and bipolar cohorts that resulted in the identification of six genome-wide …
Rare and common variants at 16p11. 2 are associated with schizophrenia
Recent studies suggest that both common and rare variants are involved in the genetic risk
of schizophrenia. Using a Cochran-Mantel-Haenszel (CMH) adjusted meta-analysis in …
of schizophrenia. Using a Cochran-Mantel-Haenszel (CMH) adjusted meta-analysis in …
Copy number variation distribution in six monozygotic twin pairs discordant for schizophrenia
CA Castellani, Z Awamleh, MG Melka… - Twin Research and …, 2014 - cambridge.org
We have evaluated copy number variants (CNVs) in six monozygotic twin pairs discordant
for schizophrenia. The data from Affymetrix® Human SNP 6.0 arrays™ were analyzed using …
for schizophrenia. The data from Affymetrix® Human SNP 6.0 arrays™ were analyzed using …
[HTML][HTML] A longitudinal twin study of the association between childhood autistic traits and psychotic experiences in adolescence
Background This twin study investigated whether autistic traits during childhood were
associated with adolescent psychotic experiences. Methods Data were collected from a …
associated with adolescent psychotic experiences. Methods Data were collected from a …
[HTML][HTML] Evolving toward a human-cell based and multiscale approach to drug discovery for CNS disorders
A disruptive approach to therapeutic discovery and development is required in order to
significantly improve the success rate of drug discovery for central nervous system (CNS) …
significantly improve the success rate of drug discovery for central nervous system (CNS) …