Hibiscus sabdariffa in Diabetes Prevention and Treatment—Does It Work? An Evidence-Based Review

D Jamrozik, W Borymska, I Kaczmarczyk-Żebrowska - Foods, 2022 - mdpi.com
Diabetes is currently a global health problem that is already reported as an epidemic. This
metabolic disease, characterized by a disturbance in the carbohydrate, protein, and lipid …

Antitubercular drugs induced liver injury: an updated insight into molecular mechanisms

D Ezhilarasan - Drug metabolism reviews, 2023 - Taylor & Francis
Tuberculosis (TB) remains a major global health burden. Antitubercular drugs (ATDs) such
as isoniazid (INH), rifampicin (RIF), pyrazinamide (PZA), and ethambutol are used as first …

Tyrosol ameliorates the symptoms of obesity, promotes adipose thermogenesis, and modulates the composition of gut microbiota in HFD fed mice

X Li, T Wei, J Li, Y Yuan, M Wu, F Chen… - Molecular Nutrition & …, 2022 - Wiley Online Library
Scope Tyrosol is one of the main polyphenolic compounds in extra virgin olive oil (EVOO)
and its role in combating obesity is unknown. Thus, this study is designed to investigate the …

STAT3 is the master regulator for the forming of 3D spheroids of 3T3-L1 preadipocytes

H Ohguro, Y Ida, F Hikage, A Umetsu, H Ichioka… - Cells, 2022 - mdpi.com
To elucidate the currently unknown mechanisms responsible for the diverse biological
aspects between two-dimensional (2D) and three-dimensional (3D) cultured 3T3-L1 …

Anthocyanin-rich extract from black beans exerts anti-diabetic effects in rats through a multi-genomic mode of action in adipose tissue

K Damián-Medina, D Milenkovic… - Frontiers in …, 2022 - frontiersin.org
Black beans (BB) are an important source of a range of plant bioactive compounds including
polyphenols, particularly anthocyanins. Several studies support that consumption of BB is …

Challenges in pharmacological intervention in perilipins (PLINs) to modulate lipid droplet dynamics in obesity and cancer

V Bombarda-Rocha, D Silva, A Badr-Eddine… - Cancers, 2023 - mdpi.com
Simple Summary This review highlights the importance of perilipins in lipid metabolism and
their potential as therapeutic targets for lipid-associated diseases like cancer and obesity …

PPARγ Gene polymorphisms, metabolic disorders, and coronary artery disease

Y Song, S Li, C He - Frontiers in Cardiovascular Medicine, 2022 - frontiersin.org
Being activated by endogenous and exogenous ligands, nuclear receptor peroxisome
proliferator-activated receptor gamma (PPARγ) enhances insulin sensitivity, promotes …

Mitochondrial dysfunction: A cellular and molecular hub in pathology of metabolic diseases and infection

T Behl, R Makkar, MK Anwer, R Hassani… - Journal of Clinical …, 2023 - mdpi.com
Mitochondria are semiautonomous doubly membraned intracellular components of cells.
The organelle comprises of an external membrane, followed by coiled structures within the …

[HTML][HTML] An Overview of the Role of Peroxisome Proliferator-activated Receptors in Liver Diseases

Z Changizi, F Kajbaf, A Moslehi - Journal of Clinical and …, 2023 - ncbi.nlm.nih.gov
Peroxisome proliferator-activated receptors (PPARs) are a superfamily of nuclear
transcription receptors, consisting of PPARα, PPARγ, and PPARβ/δ, which are highly …

Oxidative Stress and the Nrf2/PPARγ Axis in the Endometrium: Insights into Female Fertility

P Artimovič, Z Badovská, S Toporcerová, I Špaková… - Cells, 2024 - mdpi.com
Successful pregnancy depends on precise molecular regulation of uterine physiology,
especially during the menstrual cycle. Deregulated oxidative stress (OS), often influenced by …