Abstract Development of cholesteryl ester transfer protein (CETP) inhibitors for coronary
heart disease (CHD) has yet to deliver licensed medicines. To distinguish compound from …

Aims While most patients with myocardial infarction (MI) have underlying coronary
atherosclerosis, not all patients with coronary artery disease (CAD) develop MI. We sought …

Pericyte-mediated capillary constriction decreases cerebral blood flow in stroke after an
occluded artery is unblocked. The determinants of pericyte tone are poorly understood. We …

Background Epidemiological studies report associations of diverse cardiometabolic
conditions including obesity with COVID-19 illness, but causality has not been established …

Background Polygenic risk scores (PRSs) can stratify populations into cardiovascular
disease (CVD) risk groups. We aimed to quantify the potential advantage of adding …

Mendelian randomisation (MR) analysis is an important tool to elucidate the causal
relevance of environmental and biological risk factors for disease. However, causal …

INTRODUCTION White matter in the human brain serves a critical role in organizing
distributed neural networks. Diffusion magnetic resonance imaging (dMRI) has enabled the …

The incidence of stroke and dementia are diverging across the world, rising for those in low-
and middle-income countries and falling in those in high-income countries. This suggests …

Polycystic ovary syndrome (PCOS) has been associated with diabetes and cardiovascular
disease; however, whether the relationship is causal is uncertain. We conducted a two …

Background and purpose Stroke is the leading cause of mortality and disability in China.
Precise aetiological classification, imaging and biological markers may predict the prognosis …