Polygenic scores to assess atherosclerotic cardiovascular disease risk: clinical perspectives and basic implications
KG Aragam, P Natarajan - Circulation research, 2020 - Am Heart Assoc
An individual's susceptibility to atherosclerotic cardiovascular disease is influenced by
numerous clinical and lifestyle factors, motivating the multifaceted approaches currently …
numerous clinical and lifestyle factors, motivating the multifaceted approaches currently …
Genetic risk, incident stroke, and the benefits of adhering to a healthy lifestyle: cohort study of 306 473 UK Biobank participants
Objective To evaluate the associations of a polygenic risk score and healthy lifestyle with
incident stroke. Design Prospective population based cohort study. Setting UK Biobank …
incident stroke. Design Prospective population based cohort study. Setting UK Biobank …
Understanding the consequences of education inequality on cardiovascular disease: mendelian randomisation study
Objectives To investigate the role of body mass index (BMI), systolic blood pressure, and
smoking behaviour in explaining the effect of education on the risk of cardiovascular disease …
smoking behaviour in explaining the effect of education on the risk of cardiovascular disease …
[HTML][HTML] Genome-wide meta-analysis of muscle weakness identifies 15 susceptibility loci in older men and women
Low muscle strength is an important heritable indicator of poor health linked to morbidity and
mortality in older people. In a genome-wide association study meta-analysis of 256,523 …
mortality in older people. In a genome-wide association study meta-analysis of 256,523 …
[HTML][HTML] Genomic risk score offers predictive performance comparable to clinical risk factors for ischaemic stroke
Recent genome-wide association studies in stroke have enabled the generation of genomic
risk scores (GRS) but their predictive power has been modest compared to established …
risk scores (GRS) but their predictive power has been modest compared to established …
[HTML][HTML] Genome-wide association study of MRI markers of cerebral small vessel disease in 42,310 participants
E Persyn, KB Hanscombe, JMM Howson… - Nature …, 2020 - nature.com
Cerebral small vessel disease is a major cause of stroke and dementia, but its genetic basis
is incompletely understood. We perform a genetic study of three MRI markers of the disease …
is incompletely understood. We perform a genetic study of three MRI markers of the disease …
Stroke genetics: discovery, biology, and clinical applications
M Dichgans, SL Pulit, J Rosand - The Lancet Neurology, 2019 - thelancet.com
Stroke, a leading cause of long-term disability and death worldwide, has a heritable
component. Recent gene discovery efforts have expanded the number of known single …
component. Recent gene discovery efforts have expanded the number of known single …
FETCH: A deep learning-based fog computing and IoT integrated environment for healthcare monitoring and diagnosis
These days cloud-based infrastructure is facing many challenges, out of which the major
issue is their syncing data before cutover and data migration. Due to the limited scalability in …
issue is their syncing data before cutover and data migration. Due to the limited scalability in …
Genetic architecture of subcortical brain structures in 38,851 individuals
Subcortical brain structures are integral to motion, consciousness, emotions and learning.
We identified common genetic variation related to the volumes of the nucleus accumbens …
We identified common genetic variation related to the volumes of the nucleus accumbens …
The neurovascular unit and systemic biology in stroke—implications for translation and treatment
Ischaemic stroke is a leading cause of disability and death for which no acute treatments
exist beyond recanalization. The development of novel therapies has been repeatedly …
exist beyond recanalization. The development of novel therapies has been repeatedly …