Dental caries and periodontitis account for a vast burden of morbidity and healthcare
spending, yet their genetic basis remains largely uncharacterized. Here, we identify self …

Despite advances in acute management and prevention of cerebrovascular disease, stroke
and vascular cognitive impairment together remain the world's leading cause of death and …

Background: Cytokines and growth factors have been implicated in the initiation and
propagation of vascular disease. Observational studies have shown associations of their …

Background: Recent clinical guidelines support intensive blood pressure treatment targets.
However, observational data suggest that excessive diastolic blood pressure (DBP) …

Cerebral small vessel disease (cSVD) is a leading cause of ischaemic and haemorrhagic
stroke and a major contributor to dementia. Covert cSVD, which is detectable with brain MRI …

Serum urate has been implicated in hypertension and cardiovascular disease, but it is not
known whether it is exerting a causal effect. To investigate this, we performed Mendelian …

CRISPR genome editing is a promising tool for translational research but can cause
undesired editing outcomes, both on target at the edited locus and off target at other …

Three-time recipient of the AJN Book of the Year Award! The completely revised fifth edition
of this authoritative text encompasses the most current middle range theories for graduate …

The mammalian cerebrum performs high-level sensory perception, motor control and
cognitive functions through highly specialized cortical and subcortical structures. Recent …

Aims Increasing evidence implicates the microbiome as a susceptibility factor for ischaemic
stroke (IS). Interpretation of this evidence is difficult, for the composition of the microbiome is …