Over the past two decades, research has heavily emphasized basic mechanisms that
irreversibly damage brain cells after stroke. Much attention has focused on what makes …

Necrosis and apoptosis are two forms of cell death in the myocardium that have been
associated with ischemia and reperfusion. Although it has been well documented that …

Hepatic ischemia/reperfusion injury has immediate and deleterious effects on the outcome
of patients after liver surgery. The precise mechanisms leading to the damage have not …

Preconditioning to ischemic tolerance is a phenomenon in which brief episodes of a
subtoxic insult induce a robust protection against the deleterious effects of subsequent …

OBJECTIVES We investigated the effects of ischemic preconditioning (PC) on diabetic and
failing human myocardium and the role of mitochondrial KATPchannels on the response in …

Previous study suggested that cyclosporine A (CsA) could partially reduce
ischaemia/reperfusion‐induced injury in isolated heart, but the mechanism was still unclear …

Background: Sublethal periods of ischemia preceding a prolonged interval of ischaemia
protect the myocardium. This myocardial preconditioning (PC) appears to be effected by …

We used proteomics to detect regional differences in protein expression levels from
mitochondrial fractions of control, ischemia–reperfusion (IR), and ischemic preconditioned …

Exposing the heart to brief episodes of ischaemia protects the myocardium and vascular
endothelial cells against functional damage and cell death caused by subsequent …

Caspases are a family of cysteine proteases that are expressed as inactive zymogens and
undergo proteolytic maturation in a sequential manner in which initiator caspases cleave …