Gastrointestinal and brain barriers: unlocking gates of communication across the microbiota–gut–brain axis

MR Aburto, JF Cryan - Nature Reviews Gastroenterology & Hepatology, 2024 - nature.com
Crosstalk between gut and brain has long been appreciated in health and disease, and the
gut microbiota is a key player in communication between these two distant organs. Yet, the …

Protection against metabolic associated fatty liver disease by protocatechuic acid

J Tan, R Hu, J Gong, C Fang, Y Li, M Liu, Z He… - Gut …, 2023 - Taylor & Francis
Gut microbiota–diet interaction has been identified as a key factor of metabolic associated
fatty liver disease (MAFLD). Recent studies suggested that dietary polyphenols may protect …

[HTML][HTML] Gut microbiome modulates tacrolimus pharmacokinetics through the transcriptional regulation of ABCB1

AL Degraeve, V Haufroid, A Loriot, L Gatto, V Andries… - Microbiome, 2023 - Springer
Background Following solid organ transplantation, tacrolimus (TAC) is an essential drug in
the immunosuppressive strategy. Its use constitutes a challenge due to its narrow …

[HTML][HTML] New insights into bacterial mechanisms and potential intestinal epithelial cell therapeutic targets of inflammatory bowel disease

B Liang, C Wu, C Wang, W Sun, W Chen, X Hu… - Frontiers in …, 2022 - frontiersin.org
The global incidence of inflammatory bowel disease (IBD) has increased rapidly in recent
years, but its exact etiology remains unclear. In the past decade, IBD has been reported to …

Tacrolimus pharmacokinetics is associated with gut microbiota diversity in kidney transplant patients: results from a pilot cross‐sectional study

AL Degraeve, LB Bindels, V Haufroid… - Clinical …, 2024 - Wiley Online Library
Clinical use of tacrolimus (TAC), an essential immunosuppressant following transplantation,
is complexified by its high pharmacokinetic (PK) variability. The gut microbiota gains …

[HTML][HTML] Clinical significance of lipid transport function of ABC transporters in the innate immune system

S Kotlyarov, A Kotlyarova - Membranes, 2022 - mdpi.com
ABC transporters are a large family of proteins that transport a variety of substrates across
cell plasma membranes. Because of this, they are involved in many physiological …

[HTML][HTML] Multi-omics analysis revealed the differences in lipid metabolism of the gut between adult and juvenile yellowfin tuna (Thunnus albacares)

Y Zou, Y Zhang, D Wu, Z Lu, J Xiao, H Huang… - Frontiers in …, 2024 - frontiersin.org
Introduction Tuna has a cost-effective energy supply to support the regional endothermic
and high-speed swimming performance. The gut symbiotic microbiotas and their metabolites …

[HTML][HTML] Microbiota encoded fatty-acid metabolism expands tuft cells to protect tissues homeostasis during Clostridioides difficile infection in the large intestine

TD Kellogg, S Ceglia, BM Mortzfeld, AL Zeamer… - bioRxiv, 2024 - ncbi.nlm.nih.gov
Metabolic byproducts of the intestinal microbiota are crucial in maintaining host immune
tone and shaping inter-species ecological dynamics. Among these metabolites, succinate is …