Biomaterials Elicit Pyroptosis Enhancing Cancer Immunotherapy

MJ Zhang, YY Wang, LL Han, XY Liu… - Advanced Functional …, 2024 - Wiley Online Library
Cancer immunotherapy has the potential to revolutionize the treatment of malignant tumors,
but its effectiveness is limited by the low immune response rate and immune‐related …

Platinum prodrug nanoparticles with COX‐2 inhibition amplify pyroptosis for enhanced chemotherapy and immune activation of pancreatic cancer

B Yu, Y Wang, T Bing, Y Tang, J Huang… - Advanced …, 2024 - Wiley Online Library
Pyroptosis, an emerging mechanism of programmed cell death, holds great potential to
trigger a robust antitumor immune response. Platinum‐based chemotherapeutic agents can …

Lipid-and Polymer-Based Nanocarrier Platforms for Cancer Vaccine Delivery

S Sunoqrot, SA Abdel Gaber, R Abujaber… - ACS Applied Bio …, 2024 - ACS Publications
Cancer immunotherapy has gained popularity in recent years in the search for effective
treatment modalities for various malignancies, particularly those that are resistant to …

Biomimetic nanoparticle synchronizing pyroptosis induction and mitophagy inhibition for anti-tumor therapy

Y Deng, F Jia, P Jiang, L Chen, L Xing, X Shen, L Li… - Biomaterials, 2023 - Elsevier
Inducing pyroptosis in cancer cells can result in a strong anti-tumor immune response. Our
preliminary study indicates that pyroptosis can be temporarily strengthened by disrupting …

[HTML][HTML] Engineering materials for pyroptosis induction in cancer treatment

J Liu, T Chen, XL Liu, ZH Li, Y Zhang - Bioactive Materials, 2024 - Elsevier
Cancer remains a significant global health concern, necessitating the development of
innovative therapeutic strategies. This research paper aims to investigate the role of …

Sniping Cancer Stem Cells with Nanomaterials

WD Wang, YY Guo, ZL Yang, GL Su, ZJ Sun - ACS nano, 2023 - ACS Publications
Cancer stem cells (CSCs) drive tumor initiation, progression, and therapeutic resistance due
to their self-renewal and differentiation capabilities. Despite encouraging progress in cancer …

Dual-Responsive Nanomedicine Activates Programmed Antitumor Immunity through Targeting Lymphatic System

H Xiao, X Li, S Liang, S Yang, S Han, J Huang… - ACS …, 2024 - ACS Publications
Effective antitumor immunotherapy depends on evoking a cascade of cancer-immune cycles
with lymph nodes (LNs) as the initial sites for activating antitumor immunity, making drug …

A new era of cancer immunotherapy: combining revolutionary technologies for enhanced CAR-M therapy

N Li, S Geng, Z Dong, Y Jin, H Ying, HW Li, L Shi - Molecular Cancer, 2024 - Springer
Significant advancements have been made in the application of chimeric antigen receptor
(CAR)-T treatment for blood cancers during the previous ten years. However, its …

Ferritinophagy Mediated by Oxidative Stress-Driven Mitochondrial Damage Is Involved in the Polystyrene Nanoparticles-Induced Ferroptosis of Lung Injury

S Yang, T Zhang, Y Ge, Y Cheng, L Yin, Y Pu, Z Chen… - ACS …, 2023 - ACS Publications
Nanoplastics are a common type of contaminant in the air. However, no investigations have
focused on the toxic mechanism of lung injury induced by nanoplastic exposure. In the …

Hypoxia-accelerating pyroptosis nanoinducers for promoting image-guided cancer immunotherapy

D Liu, M Liang, Y Tao, H Liu, Q Liu, W Bing, W Li, J Qi - Biomaterials, 2024 - Elsevier
Precise image-guided cancer immunotherapy holds immense potential in revolutionizing
cancer treatment. The strategies facilitating activatable imaging and controlled therapeutics …