[HTML][HTML] Structural mechanisms of NLRP3 inflammasome assembly and activation
As an important sensor in the innate immune system, NLRP3 detects exogenous pathogenic
invasions and endogenous cellular damage and responds by forming the NLRP3 …
invasions and endogenous cellular damage and responds by forming the NLRP3 …
[HTML][HTML] SARS-CoV-2 pathogenesis
MM Lamers, BL Haagmans - Nature reviews microbiology, 2022 - nature.com
The emergence of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) has
caused a devastating pandemic. Although most people infected with SARS-CoV-2 develop …
caused a devastating pandemic. Although most people infected with SARS-CoV-2 develop …
[HTML][HTML] FcγR-mediated SARS-CoV-2 infection of monocytes activates inflammation
C Junqueira, Â Crespo, S Ranjbar, LB De Lacerda… - Nature, 2022 - nature.com
SARS-CoV-2 can cause acute respiratory distress and death in some patients. Although
severe COVID-19 is linked to substantial inflammation, how SARS-CoV-2 triggers …
severe COVID-19 is linked to substantial inflammation, how SARS-CoV-2 triggers …
[HTML][HTML] Inflammasome activation in infected macrophages drives COVID-19 pathology
Severe COVID-19 is characterized by persistent lung inflammation, inflammatory cytokine
production, viral RNA and a sustained interferon (IFN) response, all of which are …
production, viral RNA and a sustained interferon (IFN) response, all of which are …
[HTML][HTML] Molecular mechanisms of gasdermin D pore-forming activity
The regulated disruption of the plasma membrane, which can promote cell death, cytokine
secretion or both is central to organismal health. The protein gasdermin D (GSDMD) is a key …
secretion or both is central to organismal health. The protein gasdermin D (GSDMD) is a key …
Dying cells fan the flames of inflammation
K Newton, VM Dixit, N Kayagaki - Science, 2021 - science.org
Inflammatory processes that recruit leukocytes to injured or infected tissues are crucial for
tissue repair and the elimination of pathogens. However, excessive or chronic inflammation …
tissue repair and the elimination of pathogens. However, excessive or chronic inflammation …
[HTML][HTML] Caspase-1 and Gasdermin D afford the optimal targets with distinct switching strategies in NLRP1b inflammasome-induced cell death
Inflammasomes are essential complexes of innate immune system, which form the first line
of host defense against pathogens. Mounting evidence accumulates that inflammasome …
of host defense against pathogens. Mounting evidence accumulates that inflammasome …
[HTML][HTML] Interleukin-1 and the NLRP3 inflammasome in COVID-19: Pathogenetic and therapeutic implications
A hyperinflammatory response during severe acute respiratory syndrome coronavirus 2
(SARS-CoV-2) infection crucially worsens clinical evolution of coronavirus disease 2019 …
(SARS-CoV-2) infection crucially worsens clinical evolution of coronavirus disease 2019 …
[HTML][HTML] Cardiovascular manifestation of the BNT162b2 mRNA COVID-19 vaccine in adolescents
S Mansanguan, P Charunwatthana… - Tropical medicine and …, 2022 - mdpi.com
TropicalMed | Free Full-Text | Cardiovascular Manifestation of the BNT162b2 mRNA COVID-19
Vaccine in Adolescents Next Article in Journal Transmission Dynamics and Genomic …
Vaccine in Adolescents Next Article in Journal Transmission Dynamics and Genomic …
[HTML][HTML] Immune mechanisms underlying COVID-19 pathology and post-acute sequelae of SARS-CoV-2 infection (PASC)
With a global tally of more than 500 million cases of severe acute respiratory syndrome
coronavirus 2 (SARS-CoV-2) infections to date, there are growing concerns about the post …
coronavirus 2 (SARS-CoV-2) infections to date, there are growing concerns about the post …