Due to the advantages in efficacy and safety compared with traditional chemotherapy drugs,
targeted therapeutic drugs have become mainstream cancer treatments. Since the first …

Immune checkpoint inhibitor (ICI) activates host's anti-tumor immune response by blocking
negative regulatory immune signals. A series of clinical trials showed that ICI could …

Angiogenesis has always been the topic of major scientific interest in the field of malignant
tumors. Nowadays, targeting angiogenesis has achieved success in various carcinomas by …

Silver nanoparticles (AgNPs) have attracted a lot of interest directed towards biomedical
applications due in part to their outstanding anti-microbial activities. However, there have …

Clear cell Renal Cell Carcinoma (ccRCC) is the most common and metastatic urological
cancer. Molecular players of ccRCC progression and metastasis are not completely known …

Quinoline is an efficient scaffold for anticancer drug development as its derivatives have
shown potent results through several mechanisms like growth regulators through “apoptosis …

New EGFR inhibitor series of fifteen 5-chloro-3-hydroxymethyl-indole-2-carboxamide
derivatives has been designed, synthesized, and tested for antiproliferative activity against a …

Angiogenesis is a crucial process for tissue development, repair, and tumor survival.
Vascular endothelial growth factor (VEGF) is a key driver secreted by cancer cells …

Background Anlotinib is a tyrosine kinase inhibitor inhibiting angiogenesis. This multicenter,
randomized phase II trial aimed to investigate the efficacy and safety of anlotinib in …

Abstract Isatin (indole‐2, 3‐dione) is an oxidized indole. It is widely distributed in
mammalian tissues and body fluids, where isatin concentrations vary significantly from< 0.1 …