OBJECTIVE: To determine the effects of lens type and oxygen transmissibility on human
corneal epithelium during daily lens wear (DW). DESIGN: Prospective, randomized, double …

There are increasing demands for long-term and controlled corneal drug delivery to treat
various ocular diseases. Although biodegradable ocular inserts or contact lenses have been …

Purpose. To determine whether the eyes of high-Dk soft contact lens wearing subjects can
be discriminated from non–contact lens wearing subjects. Methods. This study was a …

Normal corneal metabolism depends on a critical level of oxygen, below which a series of
acute corneal responses occur, including an increase in stromal lactate, a reduction in …

Purpose. Silicone hydrogel (SiH) lenses offer many physiological advantages for daily wear
(DW) in addition to the continuous-wear modality for which they were originally developed …

Contact lens wear induces a wide spectrum of changes in the appearance and function of
the cornea. The most salient effect of lens wear is the hypoxically induced reduction in the …

Purpose: To evaluate the corneas of keratoconic subjects using in vivo confocal microscopy.
Methods: Slit scanning confocal microscopy was used to evaluate the central cornea of one …

Objective: To evaluate the effect of chronic cigarette smoking on dry eye parameters,
endothelial cells, and corneal thickness. Design: Prospective cross-sectional case series …

Purpose. The purpose of this study was to determine the impact of extended wear of high
and low oxygen permeability (Dk) lenses on the development or resolution of limbal …

Purpose: To study the effects of age, race, years of contact lens wear, and degree of myopia
on endothelial cell density, the coefficient of variation, and the percentage of hexagonal …